L Akhila

Bio: L Akhila is an academic researcher from Maulana Azad Medical College. The author has contributed to research in topics: Dispose pattern & Psammoma body. The author has an hindex of 3, co-authored 3 publications receiving 22 citations.

Psammocarcinoma of ovary with serous cystadenofibroma of contralateral ovary: a case report

Abstract: Introduction Psammocarcinoma of ovary is a rare serous neoplasm characterized by extensive formation of psammoma bodies, invasion of ovarian stroma, peritoneum or intraperitoneal viscera, and moderate cytological atypia. Extensive medlar search showed presence of only 28 cases of psammocarcinoma of ovary reported till date.

Faktor-faktor yang mempengaruhi tindakan masyarakat dalam membuang sampah rumah tangga di danau singkarak

Abstract: Household waste is waste that comes from daily activities in the household. Garbage can cause environmental damage, a source of disease, and disrupt public health. Many rersidents of Jorong Ombilin live on the outskirts of Lake Singkarak and there are many community actions that dispose of household waste around the lake. This study aims to determine the factors that influence people's behavior in disposing of household waste in Lake Singkarak Jorong Ombilin in 2022. This research is a quantitative study with a cross-sectional design, which was conducted from February - September 2022 with a total sample of 90 respondents in Jorong Ombilin. Sampling using systematic random sampling technique. Data were processed using SPSS and analyzed using the chi square statistical test. The results showed that 67.8% of respondents took action to dispose of household waste in the lake, 58.9% had low level of education, 68.9% had bad knowledge, 56.7% had inadequate facilities, and 70.0% assume had inappropriate supervision. There is a correlation of variables of education (p=0.011), knowledge (p=0.000), availability of facilities (p=0.000), supervision (p=0.018) with community actions. Factors that have a significant relationship with community actions in disposing of household waste in Lake Singkarak Ombilin are the level of education, knowledge, availability of facilities, and supervision. It is recommended that the local government improve supervision of community actions and providing supporting facilities, create written regulation, and impose penalty of community actions in disposing of household waste.

Plasma cell leukemia: a highly aggressive monoclonal gammopathy with a very poor prognosis.

Abstract: Plasma cell leukemia (PCL) is an aggressive variant of multiple myeloma and is characterized by the presence of >20% and/or an absolute number of greater 2 x 10(9)/L plasma cells circulating in the peripheral blood. PCL represents approximately 2-4% of all MM diagnosis and exists in two forms: primary PCL (PPCL, 60% of cases) presents de novo, whereas secondary PCL (SPCL, accounts for the remaining 40%) consists of a leukemic transformation in patients with a previously diagnosed MM. Because the mechanisms contributing to the pathogenesis of PCL are not fully understood, immunophenotyping, genetic evaluation (conventional karyotype, FISH, GEP and array-CGH), and immunohistochemistry are really important tools to investigate why plasma cells escape from bone marrow and become highly aggressive. Since treatment with standard agents and steroids is poorly effective, a combination of new drugs as part of the induction regimens and bone marrow transplant (autologous and allogeneic approaches) could nearly overcome the poor prognosis exhibited by PCL patients.

Diploid karyotype partial mole coexisting with live term fetus--case report and review of the world literature.

Abstract: A partial molar pregnancy of diploid karyotype coexisting with live term fetus is a rare entity. Most instances of partial mole are triploid and only a few cases of diploid partial moles with term delivery have been reported. Here, we report a case of partial mole concomitant with a 37-week live fetus. Postpartum karyotype of the placenta and the fetus revealed both as 46XX. Histological examination of the placenta showed a partial hydatidiform mole. We discuss the diagnosis based on presenting clinical picture and proper management of signs and symptoms of partial molar pregnancy coexisting with live term fetus and diploid karyotype, coupled with a review of the literature.

Variants in Maternal Effect Genes and Relaxed Imprinting Control in a Special Placental Mesenchymal Dysplasia Case with Mild Trophoblast Hyperplasia

Abstract: Placental mesenchymal dysplasia (PMD) and partial hydatidiform mole (PHM) placentas share similar characteristics, such as placental overgrowth and grape-like placental tissues. Distinguishing PMD from PHM is critical because the former can result in normal birth, while the latter diagnosis will lead to artificial abortion. Aneuploidy and altered dosage of imprinted gene expression are implicated in the pathogenesis of PHM and also some of the PMD cases. Diandric triploidy is the main cause of PHM, whereas mosaic diploid androgenetic cells in the placental tissue have been associated with the formation of PMD. Here, we report a very special PMD case also presenting with trophoblast hyperplasia phenotype, which is a hallmark of PHM. This PMD placenta has a normal biparental diploid karyotype and is functionally sufficient to support normal fetal growth. We took advantage of this unique case to further dissected the potential common etiology between these two diseases. We show that the differentially methylated region (DMR) at NESP55, a secondary DMR residing in the GNAS locus, is significantly hypermethylated in the PMD placenta. Furthermore, we found heterozygous mutations in NLRP2 and homozygous variants in NLRP7 in the mother's genome. NLRP2 and NLRP7 are known maternal effect genes, and their mutation in pregnant females affects fetal development. The variants/mutations in both genes have been associated with imprinting defects in mole formation and potentially contributed to the mild abnormal imprinting observed in this case. Finally, we identified heterozygous mutations in the X-linked ATRX gene, a known maternal-zygotic imprinting regulator in the patient. Overall, our study demonstrates that PMD and PHM may share overlapping etiologies with the defective/relaxed dosage control of imprinted genes, representing two extreme ends of a spectrum.

partial Mole with a coexistent Viable Fetus—A clinical dilemma: A case report with review of Literature

Abstract: Gestational trophoblastic disease encompasses a diverse group of lesions. If molar changes in the placenta are known along with an alive fetus, then situation is difficult for both obstetrician and parents. On one hand, there may be a normal pregnancy whereas on the other hand the mother may be threatened by numerous complications caused by the hydatid mole, if the pregnancy is continued. We present successfully managed case of partial molar pregnancy with an alive fetus at 1st stage of preterm labor with premature rupture of membranes with anemia with a live diploid female fetus with good neonatal out come. Follow-up till 1 year showed no progression to malignant gestational trophoblastic

Singleton Partial Molar Pregnancy Delivered in Third Trimester: A Case Report

Abstract: Background: A partial mole is the result of fertilization of a haploid ovum by two sperms or duplication of one sperm, resulting in a triploid karyotype (69 XXY, 69 XXX, 69 XYY). To date, there are very few cases of histo-pathologically confirmed partial moles with diploid karyotypes which survived. This case is reported to highlight the rarest variant of partial molar pregnancy. Case presentation: Here we present a case of singleton partial molar pregnancy co-existing with a live fetus delivered to an 18 years old primigravida lady at Jimma university medical center (JUMC) after amenorrhea of 8 months. She presented with eclamptic seizure for which she was admitted with a diagnosis of Eclampsia in 3rd trimester pregnancy. Malpresentation (breech) with? Abruptio placenta to rule out partial mole was considered initially. Cesarean section (C/S) was done to effect delivery of an alive female neonate weighing 1100 gm with an APGAR score of 4, 6 & 7 at 1st, 5th & the 10th minute of life. The neonate is admitted to neonatal intensive care unit (NICU) where she is complicated by early neonatal death after 65 hours of stay despite many efforts, the possible cause of death being respiratory failure secondary to underlying prematurity. Grossly placenta was single, weighing 1200 gm and invaded by vesicles except its membrane. Histo-pathological finding of placenta was consistent with partial mole. Conclusion: The optimal management of hydatidiform mole with coexistent live fetus is currently uncertain. Clinicians are recommended to present their individual cases for the establishment of guidelines for the management and prenatal counseling for pregnancies with partial mole with coexistent fetuses.