L
L. E. Huang
Researcher at Brigham and Women's Hospital
Publications - 2
Citations - 2306
L. E. Huang is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Gene expression & Enhancer. The author has an hindex of 2, co-authored 2 publications receiving 2222 citations.
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Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
TL;DR: The identification of an oxygen-dependent degradation (ODD) domain within HIF-1alpha that controls its degradation by the ubiquitin-proteasome pathway is reported and may provide a means of controlling gene expression by changes in oxygen tension.
Journal ArticleDOI
Erythropoietin : a model system for studying oxygen-dependent gene regulation
TL;DR: The physiological regulation of the red cell mass depends upon enhanced transcription of the erythropoietin (Epo) gene in response to hypoxia, which depends upon the selective protection of its alpha subunit from ubiquitin-dependent proteolysis by means of a mechanism that involves redox chemistry and perhaps phosphorylation.