Preparation of montmorillonite@carbon composite and its application for U(VI) removal from aqueous solution

https://northumbria-test.eprints-hosting.org/id/document/266250

Pre-treatment and extraction techniques for recovery of added value compounds from wastes throughout the agri-food chain

Cyclosporin A--a review on fermentative production, downstream processing and pharmacological applications.

Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine A (CsA) molecule by: (1) Chemical substitution and optionally deuterium substitution of amino acid 1; and (2) deuterium substitution at key sites of metabolism of the cyclosporine A molecule such as amino acids 1, 4, 9. Also disclosed are methods of producing the cyclosporine derivatives and method of producing immunosuppression with reduced toxicity with the disclosed cyclosporine derivatives.

Deuterated cyclosporine analogs and their use as immunomodulating agents

The compounds of the present invention are represented by Formula I, as shown below: 
or a pharmaceutically acceptable salt thereof,
 
with X, R 0 , R 1 , and R 2 defined herein.

Cyclosporin analogues and their pharmaceutical uses

A process is disclosed for the solution chromatographic purification of cyclosporin A from a starting mixture containing one or more of cyclosporin A, B, C, other cyclosporin components that are more polar or more apolar than cyclosporin A, and other like contaminants, by heating the starting mixture or an evaporation residue thereof to a temperature from about 80° C to about 115° C, melting the heated starting mixture, and carrying out solution chromatography of the melted material, suitably first in a 48:50:2 mixture of chloroform, dichloromethane, and ethanol, and then in a mixture of like proportions, of the solvents chloroform, ethylacetate, and ethanol

L. Hanák

Papers

Process for the purification of cyclosporin

Preparative scale separation of amino acids by using thermal ion exchange parametric pumping

Separation of amino acids with simulated moving bed chromatography

Separation of steroid compounds by overloaded preparative chromatography with precipitation in the fluid phase.

Amino acid separation by preparative temperature-swing chromatography with flow reversal