L. M. Nath

Bio: L. M. Nath is an academic researcher from University of Dhaka. The author has contributed to research in topics: Pion & Nucleon. The author has an hindex of 8, co-authored 22 publications receiving 421 citations. Previous affiliations of L. M. Nath include International Centre for Theoretical Physics & International Centre for Genetic Engineering and Biotechnology.

Photoproduction of pions at low energy

Abstract: Presented in this paper is a field theory model for photoproduction of pions at low energy. In particular, it is shown that certain interaction terms, which were previously considered to be essential in order to explain the experimental situation corresponding to the spin-3/2 resonances, are really unnecessary and that the presence of these terms are not justifiable from the theoretical point of view. Further, the free parameters in the theory representing the off-mass-shell effects of the spin-3/2 particles are fixed on the basis of theoretical considerations.

Parity-violating effects in electroproduction of the. delta. (1232) by polarized electrons

Abstract: Parity-violating effects in the (quasi)elastic scattering of longitudinally polarized electrons from spin-\textonehalf{} targets are discussed in the framework of the unified guage theories of weak and electromagnetic interactions. In particular, the $R\ensuremath{-}L$ asymmetry in electroproduction of the $\ensuremath{\Delta}(1232)$ is studied in considerable detail, taking into account the full spin-$\frac{3}{2}$ structure of this resonance. Our results are valid for all values of $E$ and the entire range of ${Q}^{2}$. Numerical predictions are given for the standard Weinberg-Salam model at several energies of the electron beam.

Quantization of the Spin- 3 2 Field in the Presence of Interactions

Abstract: The electrodynamics of spin-$\frac{3}{2}$ particles is discussed in this paper. In particular, the spin-$\frac{3}{2}$ field in the presence of the minimal electromagnetic interaction is quantized by using the Yang-Feldman formalism. The Hamiltonian for this system is obtained explicitly and the commutation relations derived in this paper are shown to be consistent with Heisenberg's equations of motion. In this formalism, the condition for the anticommutator between a spin-$\frac{3}{2}$ field and its Hermitian conjugate to be positive definite is simple to formulate.

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Abstract: Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other populations. Genome-wide association studies and subsequent meta-analyses of these two diseases as separate phenotypes have implicated previously unsuspected mechanisms, such as autophagy, in their pathogenesis and showed that some IBD loci are shared with other inflammatory diseases. Here we expand on the knowledge of relevant pathways by undertaking a meta-analysis of Crohn's disease and ulcerative colitis genome-wide association scans, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls. We identify 71 new associations, for a total of 163 IBD loci, that meet genome-wide significance thresholds. Most loci contribute to both phenotypes, and both directional (consistently favouring one allele over the course of human history) and balancing (favouring the retention of both alleles within populations) selection effects are evident. Many IBD loci are also implicated in other immune-mediated disorders, most notably with ankylosing spondylitis and psoriasis. We also observe considerable overlap between susceptibility loci for IBD and mycobacterial infection. Gene co-expression network analysis emphasizes this relationship, with pathways shared between host responses to mycobacteria and those predisposing to IBD.

Autophagy in immunity and inflammation

Abstract: Autophagy is an essential, homeostatic process by which cells break down their own components. Perhaps the most primordial function of this lysosomal degradation pathway is adaptation to nutrient deprivation. However, in complex multicellular organisms, the core molecular machinery of autophagy - the 'autophagy proteins' - orchestrates diverse aspects of cellular and organismal responses to other dangerous stimuli such as infection. Recent developments reveal a crucial role for the autophagy pathway and proteins in immunity and inflammation. They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.

Autophagy modulation as a potential therapeutic target for diverse diseases

Abstract: The lysosomal degradation pathway known as autophagy has an essential homeostatic role in controlling the quality of the cytoplasm. However, this pathway has also been implicated in the pathology of an array of human disorders. Here, Rubinsztein and colleagues provide an overview of the mechanisms and regulation of autophagy, discuss the role of this pathway in disease and highlight potential strategies for therapeutic modulation.

The challenge of new drug discovery for tuberculosis

Abstract: Tuberculosis (TB) is more prevalent in the world today than at any other time in human history Mycobacterium tuberculosis, the pathogen responsible for TB, uses diverse strategies to survive in a variety of host lesions and to evade immune surveillance A key question is how robust are our approaches to discovering new TB drugs, and what measures could be taken to reduce the long and protracted clinical development of new drugs The emergence of multi-drug-resistant strains of M tuberculosis makes the discovery of new molecular scaffolds a priority, and the current situation even necessitates the re-engineering and repositioning of some old drug families to achieve effective control Whatever the strategy used, success will depend largely on our proper understanding of the complex interactions between the pathogen and its human host In this review, we discuss innovations in TB drug discovery and evolving strategies to bring newer agents more quickly to patients