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L. Ruzicka

Bio: L. Ruzicka is an academic researcher. The author has contributed to research in topics: Steric effects & 2,3-Oxidosqualene. The author has an hindex of 3, co-authored 3 publications receiving 548 citations.

Papers
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Journal ArticleDOI
TL;DR: In this article, the biogenetic isoprene rule in its application to the triterpenes is discussed from a stereochemical standpoint, and a scheme has been developed leading from squalene to the formulae of the basic representatives of all known cyclic triterpene groups in their full structural and configurational detail.
Abstract: The biogenetic isoprene rule in its application to the triterpenes is discussed from a stereochemical standpoint. On the basis of a well defined system of arbitrary assumptions a scheme has been developed leading from squalene to the formulae of the basic representatives of all known cyclic triterpene groups - i.e. euphol, tirucallol, lupeol, taraxasterol, germanicol, β-amyrin, taraxerol, friedelin, α-amyrin, lanosterol - in their full structural and configurational detail. This result is considered to support the squalene hypothesis of the biogenesis of cyclic triterpenes.

502 citations

Journal ArticleDOI
TL;DR: In this article, it was shown that the isomeric alcohols euphol and lanosterol differ only in the configuration of carbon atoms 13, 14 and 17, and in all further structural and steric details the two alcohols are identical.
Abstract: It is shown that the isomeric alcohols euphol and lanosterol differ only in the configuration of carbon atoms 13, 14 and 17. In all further structural and steric details the two alcohols are identical.

31 citations

Journal ArticleDOI
TL;DR: In this paper, it was shown that tirucallol differs from the isomeric triterpene euphol (I) only in the configuration of carbon atom 20.1.
Abstract: 1. By degradation of the tetracyclic alcohol tirucallol (V) into the tricyclic compound XI and methyl L-(+)-2,6-dimethyl-oenanthate (X) it has been shown that tirucallol differs from the isomeric triterpene euphol (I) only in the configuration of carbon atom 20.

28 citations


Cited by
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Journal ArticleDOI
TL;DR: In this Review, highlights of a number of selected syntheses are discussed, demonstrating the enormous power of these processes in the art of total synthesis and underscore their future potential in chemical synthesis.
Abstract: In studying the evolution of organic chemistry and grasping its essence, one comes quickly to the conclusion that no other type of reaction plays as large a role in shaping this domain of science than carbon-carbon bond-forming reactions. The Grignard, Diels-Alder, and Wittig reactions are but three prominent examples of such processes, and are among those which have undeniably exercised decisive roles in the last century in the emergence of chemical synthesis as we know it today. In the last quarter of the 20th century, a new family of carbon-carbon bond-forming reactions based on transition-metal catalysts evolved as powerful tools in synthesis. Among them, the palladium-catalyzed cross-coupling reactions are the most prominent. In this Review, highlights of a number of selected syntheses are discussed. The examples chosen demonstrate the enormous power of these processes in the art of total synthesis and underscore their future potential in chemical synthesis.

2,268 citations

Journal ArticleDOI
TL;DR: The power of cascade reactions in total synthesis is illustrated in the construction of complex molecules and underscore their future potential in chemical synthesis.
Abstract: The design and implementation of cascade reactions is a challenging facet of organic chemistry, yet one that can impart striking novelty, elegance, and efficiency to synthetic strategies. The application of cascade reactions to natural products synthesis represents a particularly demanding task, but the results can be both stunning and instructive. This Review highlights selected examples of cascade reactions in total synthesis, with particular emphasis on recent applications therein. The examples discussed herein illustrate the power of these processes in the construction of complex molecules and underscore their future potential in chemical synthesis.

1,762 citations

Book
11 Sep 2006
TL;DR: It is shown that domino reactions initiated by oxidation or reduction or reduction, as well as other mechanisms, can be inhibited by various materials, such as Na6(CO3)(SO4), Na2SO4, Na2CO3, and so on.
Abstract: Introduction Cationic domino reactions Anionic domino reactions Radical domino reactions Pericyclic domino reactions Photochemically induced domino processes Transition metal catalysis Domino reactions initiated by oxidation or reduction Enzymes in domino reactions Multicomponent reactions Special techniques in domino reactions

1,337 citations

Journal ArticleDOI
TL;DR: In this paper, the authors discuss the effect of leistungsfahigen Reaktionen on the Potenzial f f zukunftige chemischen Synthesen unterstreichen, i. e.g., palladiumkatalysierten Kreuzkupplungen.
Abstract: Wenn man die Entwicklung der organischen Chemie betrachtet, kommt man schnell zu dem Schluss, dass kein Reaktionstyp dieses Gebiet in vergleichbarer Weise gepragt hat wie die Kohlenstoff-Kohlenstoff-Kupplungen. Grignard-, Diels-Alder- und Wittig-Reaktionen sind nur drei herausragende Beispiele fur solche Prozesse, die im vergangenen Jahrhundert zweifellos entscheidend am Aufstieg der chemischen Synthese beteiligt waren. Im letzten Viertel des 20. Jahrhunderts bereicherte eine neue Familie von leistungsfahigen Reaktionen zur Knupfung von Kohlenstoff-Kohlenstoff-Bindungen das Repertoire der Synthesechemie: die ubergangsmetallkatalysierten Reaktionen, allen voran die palladiumkatalysierten Kreuzkupplungen. In diesem Aufsatz werden Auszuge aus einer Reihe von ausgewahlten Synthesen diskutiert. Die Beispiele sollen die enorme Leistungsfahigkeit dieser Prozesse in der Kunst der Totalsynthese aufzeigen und ihr Potenzial fur zukunftige chemische Synthesen unterstreichen.

565 citations