Author
Laila F. Awad
Bio: Laila F. Awad is an academic researcher from Alexandria University. The author has contributed to research in topics: Acetic anhydride & Dimedone. The author has an hindex of 14, co-authored 66 publications receiving 582 citations.
Topics: Acetic anhydride, Dimedone, Alkylation, Chemistry, Aryl
Papers published on a yearly basis
Papers
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71 citations
TL;DR: In this article, the authors showed that reaction of diethyl galactrate (17) with 3 gave 1,4-bis (4-amino-5-mercapto-1,2,3,4,5,6-hexa- O -acetyl- d- glycero - d- gulo hexitol-1-yl)-6-methyl-1.4-b ]1,3-4-thiadiazol-3-yl.
62 citations
TL;DR: In this article, the diazonium salt of 4-aminoantipyrine was coupled with dimedone to yield 2,3-dimethyl-4-[2-(5,5-dimmethyl- 2,6-dioxocyclohex-2-ylidend)-hydrazino]-5-oxo-1-phenylpyrazoline (3).
Abstract: Coupling of dimedone with the diazonium salt of 4-aminoantipyrine afforded 2,3-dimethyl-4-[2-(5,5-dimethyl- 2,6-dioxocyclohex-2-ylidend)-hydrazino]-5-oxo-1-phenylpyrazoline (3). Reaction of 3 with excess phenylhydrazine gave the mixed trishydrazone derivative 4. Treatment of 3 with hydroxylamine produced the bisoxime 5 which upon dehydrative cyclization with acetic anhydride gave the corrsponding tetrahydrobenzo[d][1,2,3]triazole derivative 7. A one-pot synthesis of 7 was done by reacting 3 with hydroxylamine hydrochloride in pyridine, followed by heatment with acetic anhydride.
31 citations
TL;DR: The design, synthesis and optimization of novel MMP-10/13 inhibitors with enhanced M MP-10 potency and selectivity towards polypharmacology are described and point to 16 as the most promising compound in this study.
28 citations
TL;DR: Methyl 3-O-(β-D-mannopyranosyl)-α-Dmannopeyranoside was synthesized by the reaction of 3,4,6-tri-O-benzyl-2,O-tolylsulfonyl-1-O-,tresyl-D-,D-manopyranose with methyl 2, 4,6,tri-o-bensyl-and 2,4-6-treesyl-mixture, followed by deprotection as mentioned in this paper.
Abstract: Methyl 3-O-(β-D-mannopyranosyl)-α-D-mannopyranoside was synthesized by the reaction of 3,4,6-tri-O-benzyl-2-O-benzylsulfonyl-1-O-tresyl-D-mannopyranose with methyl 2,4,6-tri-O-benzyl- and 2,4,6-tri-O-(p-bromobenzyl)-α-D-mannopyranoside, followed by deprotection. The corresponding 1-O-(β-tolylsulfonyl)derivative gave better yield and stereoselectivity in the reaction with methanol, but was not sufficiently reactive to couple with a hindered secondary alcohol. The 2-O-benzylsulfonyl group is comparable in β-directing effect to 2-O-methylsulfonyl group, but its stereoselectivity is dependent on the structure of the reactant alcohol. It can be selectively removed by the reaction with sodium amide in N,N-dimethylformamide.
27 citations
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TL;DR: New principles for the formation of glycoside bonds are discussed and developments, mainly in the last ten years, that have led to significant advances in oligosaccharide and glycoconjugate synthesis have been compiled and are evaluated.
Abstract: Increased understanding of the important roles that oligosaccharides and glycoconjugates play in biological processes has led to a demand for significant amounts of these materials for biological, medicinal, and pharmacological studies. Therefore, tremendous effort has been made to develop new procedures for the synthesis of glycosides, whereby the main focus is often the formation of the glycosidic bonds. Accordingly, quite a few review articles have been published over the past few years on glycoside synthesis; however, most are confined to either a specific type of glycoside or a specific strategy for glycoside synthesis. In this Review, new principles for the formation of glycoside bonds are discussed. Developments, mainly in the last ten years, that have led to significant advances in oligosaccharide and glycoconjugate synthesis have been compiled and are evaluated.
741 citations
TL;DR: The chemical, physical, and processing solutions suggested in the scientific and patent literature to improve storage stability are extensively discussed, with particular attention to an emerging class of asphalt binders in which the technologies of polymer-modified asphalts and polymer nanocomposites are combined.
394 citations
Patent•
23 May 2001
TL;DR: A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided in this paper.
Abstract: A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
248 citations
TL;DR: In this article, the application of heterogeneous catalysis combined with microwave irradiation in the synthesis of heterocyclic compounds is reviewed and the authors highlight the environmentally benign and sustainable nature of the combined microwave-assisted heterogeneous catalytic methods, highlighting the green aspects of individual synthetic approaches.
205 citations
TL;DR: The reaction products of DAF-2 with DHA and AA have been characterized using capillary electrophoresis with laser-induced fluorescence detection and electrospray mass spectrometry, indicating the importance of understanding this chemistry.
192 citations