L
Lalita Ramakrishnan
Researcher at Laboratory of Molecular Biology
Publications - 113
Citations - 13550
Lalita Ramakrishnan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Mycobacterium marinum & Mycobacterium tuberculosis. The author has an hindex of 55, co-authored 106 publications receiving 11766 citations. Previous affiliations of Lalita Ramakrishnan include University of Cambridge & Stanford University.
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The role of the granuloma in expansion and dissemination of early tuberculous infection.
TL;DR: In this paper, the authors use quantitative intravital microscopy to reveal distinct steps of granuloma formation and assess their consequence for infection, showing that pathogenic mycobacteria exploit the granulomas during the innate immune phase for local expansion and systemic dissemination.
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Revisiting the role of the granuloma in tuberculosis
TL;DR: Surprising new discoveries are discussed that implicate the innate immune mechanisms of the tuberculous granuloma in the expansion and dissemination of infection and why this structure can fail to eradicate infection even after adaptive immunity develops.
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Real-time visualization of Mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos
J. Muse Davis,Hilary Clay,Jessica L. Lewis,Nafisa Ghori,Philippe Herbomel,Lalita Ramakrishnan +5 more
TL;DR: Optical transparency of zebrafish embryos is exploited to image the events of M. marinum infection in vivo and shows how infection can redirect normal embryonic macrophage migration, even recruiting macrophages seemingly committed to their developmentally dictated tissue sites.
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Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis
Timothy P. Stinear,Torsten Seemann,Paul Harrison,Grant A. Jenkin,John K. Davies,Paul D R Johnson,Zahra Abdellah,Claire Arrowsmith,Tracey Chillingworth,Carol Churcher,Kay Clarke,Ann Cronin,Paul Davis,Ian Goodhead,Nancy Holroyd,Kay Jagels,Angela Lord,Sharon Moule,Karen Mungall,Halina Norbertczak,Michael A. Quail,Ester Rabbinowitsch,Danielle Walker,Brian White,Sally Whitehead,Pamela L. C. Small,Roland Brosch,Lalita Ramakrishnan,Michael A. Fischbach,Julian Parkhill,Stewart T. Cole +30 more
TL;DR: The genome of the M strain of M. marinum comprises a 6,636,827-bp circular chromosome with 5424 CDS, 10 prophages, and a 23-kb mercury-resistance plasmid as discussed by the authors.
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TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species
TL;DR: Using the zebrafish, the cyclophilin D-inhibiting drug alisporivir and the acid sphingomyelinase-inactivating drug, desipramine, synergize to reverse susceptibility, suggesting the therapeutic potential of these orally active drugs against tuberculosis and possibly other TNF-mediated diseases.