scispace - formally typeset
Search or ask a question
Author

Lalitkumar K. Vora

Bio: Lalitkumar K. Vora is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Medicine & Drug delivery. The author has an hindex of 14, co-authored 38 publications receiving 539 citations. Previous affiliations of Lalitkumar K. Vora include Institute of Chemical Technology.

Papers published on a yearly basis

Papers
More filters
Journal ArticleDOI
TL;DR: In this paper, the authors provide an overview of nasal vaccines with a focus on formulation development as well as ongoing preclinical and clinical studies for SARS-CoV-2 intranasal vaccine products.

117 citations

Journal ArticleDOI
TL;DR: This review covered the different types of MNs loaded with different nano/biotherapeutics for long-acting delivery for a wide range of potential clinical applications and outlined the future development scenario of such long- acting MN delivery systems for different disease conditions to achieve improved clinical benefit.

100 citations

Journal ArticleDOI
TL;DR: The two‐stage novel processing strategy developed here provides a simple and easy method for localising particulate delivery systems into dissolving MN, and may serve as promising means for controlled transdermal delivery and targeted intradermal administration.

98 citations

Journal ArticleDOI
TL;DR: For the first time, the preparation and characterisation of a DMN system from the carbohydrate biopolymer, pullulan (PL) is reported, demonstrating that PL DMNs may serve as a promising tool for efficient transdermal drug delivery.

95 citations

Journal ArticleDOI
TL;DR: The integrated patch produced in this work represents a promising minimally invasive transdermal drug delivery system that can overcome the skin barrier and deliver MTX in a sustained manner, which may help in minimising or even avoiding the nausea and vomiting, associated with the conventional administration routes.

82 citations


Cited by
More filters
01 Apr 2010
TL;DR: Polycaprolactone (PCL) was used in the biomaterials field and a number of drug-delivery devices for up to 3-4 years as discussed by the authors.
Abstract: During the resorbable-polymer-boom of the 1970s and 1980s, polycaprolactone (PCL) was used in the biomaterials field and a number of drug-delivery devices. Its popularity was soon superseded by faster resorbable polymers which had fewer perceived disadvantages associated with long term degradation (up to 3-4 years) and intracellular resorption pathways; consequently, PCL was almost forgotten for most of two decades. Recently, a resurgence of interest has propelled PCL back into the biomaterials-arena. The superior rheological and viscoelastic properties over many of its aliphatic polyester counterparts renders PCL easy to manufacture and manipulate into a large range of implants and devices. Coupled with relatively inexpensive production routes and FDA approval, this provides a promising platform for the production of longer-term degradable implants which may be manipulated physically, chemically and biologically to possess tailorable degradation kinetics to suit a specific anatomical site. This review will discuss the application of PCL as a biomaterial over the last two decades focusing on the advantages which have propagated its return into the spotlight with a particular focus on medical devices, drug delivery and tissue engineering.

480 citations

Journal ArticleDOI
TL;DR: This review surveys the current design and use of polymeric MNs for transdermal protein delivery and discusses the clinical potential and future translation of MNs.

217 citations

Journal ArticleDOI
TL;DR: This review presents elaborated discussion on role of pullulan and its derivatives in various biomedical applications e.g. drug delivery, gene targeting, tissue engineering, vaccination, plasma substitution, chaperone-like activity, medical imaging, insulinotropic activity, pharmaceutical dosages formation, coating, etc.

202 citations

Journal ArticleDOI
TL;DR: The past and current techniques available for fabricating and remotely controlling drug delivery systems are reviewed and the application of new technologies (e.g. 3D printing) in this field are addressed.

202 citations

Journal ArticleDOI
TL;DR: In the present review, skin anatomy and its barriers along with skin infection are discussed, and potential strategies for designing antimicrobial microneedles and their targeted therapy are outlined.
Abstract: Skin infections caused by bacteria, viruses and fungi are difficult to treat by conventional topical administration because of poor drug penetration across the stratum corneum This results in low bioavailability of drugs to the infection site, as well as the lack of prolonged release Emerging antimicrobial transdermal and ocular microneedle patches have become promising medical devices for the delivery of various antibacterial, antifungal, and antiviral therapeutics In the present review, skin anatomy and its barriers along with skin infection are discussed Potential strategies for designing antimicrobial microneedles and their targeted therapy are outlined Finally, biosensing microneedle patches associated with personalized drug therapy and selective toxicity toward specific microbial species are discussed

188 citations