L
Lao H. Saal
Researcher at Lund University
Publications - 90
Citations - 10030
Lao H. Saal is an academic researcher from Lund University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 31, co-authored 76 publications receiving 8964 citations. Previous affiliations of Lao H. Saal include National Institutes of Health & Columbia University Medical Center.
Papers
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Journal ArticleDOI
Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks
Javed Khan,Jun S. Wei,Markus Ringnér,Markus Ringnér,Lao H. Saal,Marc Ladanyi,Frank Westermann,Frank Berthold,Manfred Schwab,Cristina R. Antonescu,Carsten Peterson,Paul S. Meltzer +11 more
TL;DR: The ability of the trained ANN models to recognize SRBCTs is demonstrated, and the potential applications of these methods for tumor diagnosis and the identification of candidate targets for therapy are demonstrated.
Journal ArticleDOI
PIK3CA Mutations Correlate with Hormone Receptors, Node Metastasis, and ERBB2, and Are Mutually Exclusive with PTEN Loss in Human Breast Carcinoma
Lao H. Saal,Karolina Holm,Matthew Maurer,Lorenzo Memeo,Tao Su,Xiaomei Wang,Jennifer S. Yu,Per-Uno Malmström,Mahesh Mansukhani,Jens Enoksson,Hanina Hibshoosh,Åke Borg,Ramon Parsons +12 more
TL;DR: Mutation of PIK3CA is frequent, occurs early in carcinoma development, and has prognostic and therapeutic implications and the association between ERBB2 overexpression and Pik3CA mutation implies that more than one input activating the PI3K/AKT pathway may be required to overcome intact PTEN.
Journal Article
Estrogen Receptor Status in Breast Cancer Is Associated with Remarkably Distinct Gene Expression Patterns
Sofia Gruvberger,Markus Ringnér,Yi Chen,Sujatha Panavally,Lao H. Saal,Åke Borg,Mårten Fernö,Carsten Peterson,Paul S. Meltzer +8 more
TL;DR: The results provide evidence that ER+ and ER- tumors display remarkably different gene-expression phenotypes not solely explained by differences in estrogen responsiveness, and could accurately predict ER status even when excluding top discriminator genes, including ER itself.
Journal ArticleDOI
The CD44+/CD24- phenotype is enriched in basal-like breast tumors
Gabriella Honeth,Pär-Ola Bendahl,Markus Ringnér,Lao H. Saal,Lao H. Saal,Sofia K. Gruvberger-Saal,Sofia K. Gruvberger-Saal,Kristina Lövgren,Dorthe Grabau,Mårten Fernö,Åke Borg,Cecilia Hegardt +11 more
TL;DR: In this paper, the authors explored the prevalence of cells with different CD44/CD24 phenotypes within breast cancer subtypes and demonstrated an association between basal-like and particularly BRCA1 hereditary breast cancer and the presence of CD44+/cd24- cells.
Journal ArticleDOI
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
Lao H. Saal,Peter Johansson,Karolina Holm,Sofia K. Gruvberger-Saal,Qing-Bai She,Matthew J. Maurer,Susan Koujak,Adolfo A. Ferrando,Per-Uno Malmström,Lorenzo Memeo,Jorma Isola,Pär-Ola Bendahl,Neal Rosen,Hanina Hibshoosh,Markus Ringnér,Åke Borg,Ramon Parsons +16 more
TL;DR: It is indicated that aberrant PI3K pathway signaling is strongly associated with metastasis and poor survival across carcinoma types, highlighting the enormous potential impact on patient survival that pathway inhibition could achieve.