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Laramie E. Duncan

Researcher at Stanford University

Publications -  77
Citations -  23971

Laramie E. Duncan is an academic researcher from Stanford University. The author has contributed to research in topics: Genome-wide association study & Bipolar disorder. The author has an hindex of 31, co-authored 71 publications receiving 18849 citations. Previous affiliations of Laramie E. Duncan include University of Colorado Boulder & Broad Institute.

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Analysis of protein-coding genetic variation in 60,706 humans

Monkol Lek, +106 more
- 18 Aug 2016 - 
TL;DR: The aggregation and analysis of high-quality exome (protein-coding region) DNA sequence data for 60,706 individuals of diverse ancestries generated as part of the Exome Aggregation Consortium (ExAC) provides direct evidence for the presence of widespread mutational recurrence.
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An atlas of genetic correlations across human diseases and traits.

Brendan Bulik-Sullivan, +20 more
- 28 Sep 2015 - 
TL;DR: This work introduces a technique—cross-trait LD Score regression—for estimating genetic correlation that requires only GWAS summary statistics and is not biased by sample overlap, and uses this method to estimate 276 genetic correlations among 24 traits.
Posted ContentDOI

Analysis of protein-coding genetic variation in 60,706 humans

Monkol Lek, +72 more
- 30 Oct 2015 - 
TL;DR: The aggregation and analysis of high-quality exome (protein-coding region) sequence data for 60,706 individuals of diverse ethnicities generated as part of the Exome Aggregation Consortium (ExAC) provides direct evidence for the presence of widespread mutational recurrence.
Journal ArticleDOI

Analysis of shared heritability in common disorders of the brain

Verneri Anttila, +720 more
- 22 Jun 2018 - 
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
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A polygenic burden of rare disruptive mutations in schizophrenia

Shaun Purcell, +31 more
- 13 Feb 2014 - 
TL;DR: In this article, the exome sequences of 2,536 schizophrenia cases and 2,543 controls were analyzed and the authors demonstrated a polygenic burden primarily arising from rare (less than 1 in 10,000), disruptive mutations distributed across many genes.