L
Larry E. Overman
Researcher at University of California, Irvine
Publications - 614
Citations - 25796
Larry E. Overman is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Total synthesis & Enantioselective synthesis. The author has an hindex of 81, co-authored 614 publications receiving 24201 citations. Previous affiliations of Larry E. Overman include University of Toronto & University of London.
Papers
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The asymmetric intramolecular Heck reaction in natural product total synthesis.
Amy B. Dounay,Larry E. Overman +1 more
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Catalytic asymmetric synthesis of all-carbon quaternary stereocenters
TL;DR: Only a few catalytic asymmetric C-C bond-forming reactions have been shown to be useful for constructing all-carbon quaternary stereocenters and this Perspective examines the current state of such methods.
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Catalytic enantioselective synthesis of quaternary carbon stereocentres
TL;DR: The many catalytic enantioselective reactions developed during the past decade for the synthesis of single stereoisomers of such organic molecules make it possible to incorporate quaternary stereocentres selectively in many organic molecules that are useful in medicine, agriculture and potentially other areas such as flavouring, fragrances and materials.
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Total synthesis of complex cyclotryptamine alkaloids: stereocontrolled construction of quaternary carbon stereocenters.
Alan Steven,Larry E. Overman +1 more
TL;DR: This review tells the story behind the development of this toolbox of synthetic methods, and their validation through the total synthesis of a number of structurally complex cyclotryptamine alkaloids, and highlights an aspect of asymmetric catalysis that has received little attention.
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Contiguous stereogenic quaternary carbons: A daunting challenge in natural products synthesis
TL;DR: In this paper, the most useful transformations and strategies devised recently for directly assembling all-carbon quaternary stereocenters are examined and compared, as well as their application in the context of chemical synthesis.