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Larry J. Diaz

Bio: Larry J. Diaz is an academic researcher from Harvard University. The author has contributed to research in topics: Coronary artery disease & Spiral computed tomography. The author has an hindex of 1, co-authored 1 publications receiving 423 citations.

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TL;DR: For all coronary segments included, 16-slice MDCT has moderate diagnostic value for the detection of significant obstructive coronary artery stenosis in a population with a high prevalence of CAD and suggests a limited impact on clinical decision-making in high-risk populations.
Abstract: Background— In this study, we investigated the diagnostic value and limitations of multidetector computed tomography (MDCT)–based noninvasive detection of significant obstructive coronary artery disease (CAD) in a consecutive high-risk patient population with inclusion of all coronary segments. Methods and Results— In a prospective, blinded, standard cross-sectional technology assessment, a cohort of 33 consecutive patients with a positive stress test result underwent 16-slice MDCT and selective coronary angiography for the detection of significant obstructive CAD. We assessed the diagnostic accuracy of MDCT in a segment-based and a patient-based model and determined the impact of stenosis location and the presence of calcification on diagnostic accuracy in both models. Analysis of all 530 coronary segments demonstrated moderate sensitivity (63%) and excellent specificity (96%) with a moderate positive predictive value of 64% and an excellent negative predictive value (NPV) of 96% for the detection of sig...

429 citations


Cited by
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Journal ArticleDOI
TL;DR: Evaluated diagnostic accuracy of multislice computed tomography (MSCT) coronary angiography using a new 64-slice scanner indicates high quantitative and qualitative diagnostic accuracy in comparison to QCA in a broad spectrum of patients.

1,503 citations

Journal ArticleDOI
TL;DR: The utility and limitations of generations of cardiac CT systems are reviewed, with emphasis on CT measurement of CAD and coronary artery calcified plaque (CACP) and noncalcified plaque.
Abstract: This scientific statement reviews the scientific data for cardiac computed tomography (CT) related to imaging of coronary artery disease (CAD) and atherosclerosis. Cardiac CT is a CT imaging technique that accounts for cardiac motion, typically through the use of ECG gating. The utility and limitations of generations of cardiac CT systems are reviewed in this statement with emphasis on CT measurement of CAD and coronary artery calcified plaque (CACP) and noncalcified plaque. Successive generations of CT technology have been applied to cardiac imaging beginning in the early 1980s with conventional CT, electron beam CT (EBCT) in 1987, and multidetector CT (MDCT) in 1999. Compared with other imaging modalities, cardiac CT has undergone an accelerated …

1,348 citations

Journal ArticleDOI
TL;DR: In this article, the diagnostic accuracy of 64-slice computed tomography (CT) to identify and quantify atherosclerotic coronary lesions in comparison with catheter-based angiography and intravascular ultrasound (IVUS) was evaluated.

1,169 citations

Journal ArticleDOI
TL;DR: The concept of noninvasive detection and characterization of coronary atherosclerotic lesions in patients with ACS by MDCT is introduced and differences in lesion morphology and plaque composition are identified, consistent with previous intravascular ultrasound studies.

538 citations

Journal ArticleDOI
TL;DR: Fifty percent of patients with acute chest pain and low to intermediate likelihood of ACS were free of CAD by computed tomography and had no ACS, suggesting early coronary CTA may significantly improve patient management in the emergency department.

537 citations