L
Lars-Gustav Lundin
Researcher at Uppsala University
Publications - 14
Citations - 3350
Lars-Gustav Lundin is an academic researcher from Uppsala University. The author has contributed to research in topics: Gene & 2R hypothesis. The author has an hindex of 10, co-authored 14 publications receiving 3108 citations.
Papers
More filters
Journal ArticleDOI
The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families : Phylogenetic Analysis, Paralogon Groups, and Fingerprints
TL;DR: This study represents the first overall map of the GPCR sequences in a single mammalian genome and shows several common structural features indicating that the human GPCRs in the GRAFS families share a common ancestor.
Journal ArticleDOI
The human Hox-bearing chromosome regions did arise by block or chromosome (or even genome) duplications.
TL;DR: It is concluded that all relevant and analyzable families support or are consistent with block/chromosome duplications and that none clearly contradicts the 2R hypothesis.
Journal ArticleDOI
Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates
TL;DR: It is argued that gene localization data and the delineation of paralogous chromosomal regions give more reliable information about these types of events than dendrograms of gene families as gene relationships are often obscured by uneven replacement rates as well as other factors.
Journal ArticleDOI
Evolution of the Neuropeptide Y Receptor Family: Gene and Chromosome Duplications Deduced from the Cloning and Mapping of the Five Receptor Subtype Genes in Pig
Amanda Wraith,A. Törnsten,Patrick Chardon,I. Harbitz,Bhanu P. Chowdhary,Leif Andersson,Lars-Gustav Lundin,Dan Larhammar +7 more
TL;DR: The sequence comparisons suggest that the tight cluster of NPY1R, NPY2R, and NPY5R on human chromosome 4 (HSA4) represents the ancestral configuration, whereas the porcine cluster has been split by two inversions on SSC8.
Journal ArticleDOI
Early vertebrate chromosome duplications and the evolution of the neuropeptide Y receptor gene regions
Tomas A. Larsson,Frida Olsson,Görel Sundström,Lars-Gustav Lundin,Sydney Brenner,Byrappa Venkatesh,Dan Larhammar +6 more
TL;DR: In five vertebrate genomes, 45 gene families with members close to the NPY receptor genes in the compact genomes of the teleost fishes Tetraodon nigroviridis and Takifugu rubripes are investigated, finding that the phylogenetic analyses and chromosomal locations of these gene families support duplications of large blocks of genes or even entire chromosomes.