Lars M. Ittner

TL;DR: It is shown that tau, known as axonal protein, has a dendritic function in postsynaptic targeting of the Src kinase Fyn, a substrate of which is the NMDA receptor (NR), which uncouples NR-mediated excitotoxicity and hence mitigates Abeta toxicity.

TL;DR: Novel findings that have shifted understanding of the role of tau in the pathogenesis of Alzheimer's disease towards being a crucial partner of amyloid-β are reviewed.

TL;DR: This review summarizes what has been learned about the roles of these proteins from transgenic mice and invertebrate species such as flies and worms and suggests an early, preclinical diagnosis of AD and FTD could be within reach.

TL;DR: A molecular link between Aβ and tau protein in AD pathology in vivo is established, illustrating the potential of quantitative proteomics and establishing synergistic, age-associated effects of A β and t Tau in perishing mitochondria.

TL;DR: The circumstances under which CD8+ T cells specific for pancreatic beta-islet antigens induce disease in mice expressing lymphocytic choriomeningitis virus as a transgene under the control of the rat insulin promoter are investigated to identify the 'inflammatory status' of the target organ as a separate and limiting factor determining the development of autoimmune disease.