Lars Öhman

TL;DR: The crystal structures of the LBD of ER in complex with the endogenous oestrogen, 17β-oestradiol, and the selective antagonist raloxifene provide a molecular basis for the distinctive pharmacophore of the ER and its catholic binding properties.

TL;DR: All three RU-486 GR-LBD structures show that GR has a very flexible region between the end of helix 11 and the endof helix 12, and the subunits of the GR3 dimers are covalently connected via a disulfide bond between the Cys-736 residues in the two molecules.

TL;DR: It is suggested that proliferation of Spodoptera frugiperda (Sf9 insect cells), a normal cell line able to grow in a serum-free medium without any added growth factors, is regulated by autocrine growth factors and possibly by other regulatory mechanisms.

TL;DR: The recombinant PAP should be useful in future studies on the properties and regulation of the mammalian PAP enzyme, and was shown to be substituted with N-linked oligosaccharides.

TL;DR: Overall, A-348441 demonstrates that an LSGRA is sufficient to reduce elevated HGO and normalize blood glucose and may provide a new therapeutic approach for the treatment of type 2 diabetes.