L
Larson Hogstrom
Researcher at Broad Institute
Publications - 11
Citations - 3583
Larson Hogstrom is an academic researcher from Broad Institute. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 8, co-authored 10 publications receiving 1868 citations. Previous affiliations of Larson Hogstrom include Massachusetts Institute of Technology.
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Journal ArticleDOI
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Aravind Subramanian,Rajiv Narayan,Steven M. Corsello,Steven M. Corsello,David Peck,Ted Natoli,Xiaodong Lu,Joshua Gould,John F. Davis,Andrew A. Tubelli,Jacob K. Asiedu,David L. Lahr,Jodi E. Hirschman,Zihan Liu,Melanie Donahue,Bina Julian,Mariya Khan,David Wadden,Ian Smith,Daniel D. Lam,Arthur Liberzon,Courtney Toder,Mukta Bagul,Marek Orzechowski,Oana M. Enache,Federica Piccioni,Sarah A. Johnson,Nicholas J. Lyons,Alice H. Berger,Alice H. Berger,Alykhan F. Shamji,Angela N. Brooks,Angela N. Brooks,Anita Vrcic,Corey Flynn,Jacqueline Rosains,David Y. Takeda,David Y. Takeda,Roger Hu,Desiree Davison,Justin Lamb,Kristin Ardlie,Larson Hogstrom,Peyton Greenside,Nathanael S. Gray,Nathanael S. Gray,Paul A. Clemons,Serena J. Silver,Xiaoyun Wu,Wen-Ning Zhao,Wen-Ning Zhao,Willis Read-Button,Xiaohua Wu,Stephen J. Haggarty,Stephen J. Haggarty,Lucienne Ronco,Jesse S. Boehm,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber,John G. Doench,Joshua A. Bittker,David E. Root,Bang Wong,Todd R. Golub +64 more
TL;DR: The expanded CMap is reported, made possible by a new, low-cost, high-throughput reduced representation expression profiling method that is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.
Posted ContentDOI
A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles
Aravind Subramanian,Rajiv Narayan,Steven M. Corsello,David Peck,Ted Natoli,Xiaodong Lu,Joshua Gould,John F. Davis,Andrew A. Tubelli,Jacob K. Asiedu,David L. Lahr,Jodi E. Hirschman,Zihan Liu,Melanie Donahue,Bina Julian,Mariya Khan,David Wadden,Ian Smith,Daniel D. Lam,Arthur Liberzon,Courtney Toder,Mukta Bagul,Marek Orzechowski,Oana M. Enache,Federica Piccioni,Alice H. Berger,Alykhan F. Shamji,Angela N. Brooks,Anita Vrcic,Corey Flynn,Jacqueline Rosains,David Y. Takeda,Desiree Davison,Justin Lamb,Kristin Ardlie,Larson Hogstrom,Nathanael S. Gray,Paul A. Clemons,Serena J. Silver,Xiaoyun Wu,Wen-Ning Zhao,Willis Read-Button,Xiaohua Wu,Stephen J. Haggarty,Lucienne Ronco,Jesse S. Boehm,Stuart L. Schreiber,John G. Doench,Joshua A. Bittker,David E. Root,Bang Wong,Todd R. Golub +51 more
TL;DR: A new, low-cost, high throughput reduced representation expression profiling method, L1000, is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.
Journal ArticleDOI
Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life
Moran Yassour,Moran Yassour,Moran Yassour,Eeva Jason,Larson Hogstrom,Timothy D. Arthur,Surya Tripathi,Heli Siljander,Jenni Selvenius,Sami Oikarinen,Heikki Hyöty,Suvi M. Virtanen,Jorma Ilonen,Pamela Ferretti,Edoardo Pasolli,Adrian Tett,Francesco Asnicar,Nicola Segata,Hera Vlamakis,Eric S. Lander,Curtis Huttenhower,Mikael Knip,Ramnik J. Xavier,Ramnik J. Xavier,Ramnik J. Xavier +24 more
TL;DR: In families where the secondary strain of B. uniformis was inherited, a starch utilization gene cluster that was absent in the mother's dominant strain was identified in the child, suggesting the selective advantage of a mother's secondary strain in the infant gut.
Journal ArticleDOI
The NORAD lncRNA assembles a topoisomerase complex critical for genome stability.
Mathias Munschauer,Celina T. Nguyen,Klara Sirokman,Christina R. Hartigan,Larson Hogstrom,Jesse M. Engreitz,Jacob C. Ulirsch,Jacob C. Ulirsch,Charles P. Fulco,Vidya Subramanian,Jenny Chen,Jenny Chen,Monica Schenone,Mitchell Guttman,Steven A. Carr,Eric S. Lander,Eric S. Lander,Eric S. Lander +17 more
TL;DR: The results demonstrate that the interaction between NORAD and RBMX is important for NORAD function, and that NORAD is required for the assembly of the previously unknown topoisomerase complex NARC1, which contributes to maintaining genomic stability.
Journal ArticleDOI
High-throughput Phenotyping of Lung Cancer Somatic Mutations
Alice H. Berger,Alice H. Berger,Angela N. Brooks,Angela N. Brooks,Xiaoyun Wu,Yashaswi Shrestha,Candace R. Chouinard,Federica Piccioni,Mukta Bagul,Atanas Kamburov,Atanas Kamburov,Marcin Imielinski,Marcin Imielinski,Larson Hogstrom,Cong Zhu,Xiaoping Yang,Sasha Pantel,Ryo Sakai,Jacqueline Watson,Jacqueline Watson,Nathan O. Kaplan,Joshua D. Campbell,Joshua D. Campbell,Shantanu Singh,David E. Root,Rajiv Narayan,Ted Natoli,David L. Lahr,Itay Tirosh,Pablo Tamayo,Gad Getz,Gad Getz,Bang Wong,John G. Doench,Aravind Subramanian,Todd R. Golub,Todd R. Golub,Matthew Meyerson,Matthew Meyerson,Jesse S. Boehm +39 more
TL;DR: Among these impactful variants are rare somatic, clinically actionable variants including EGFR S645C, ARAF S214C and S214F, ERBB2 S418T, and multiple BRAF variants, demonstrating that rare mutations can be functionally important in cancer.