L
Lasse Pihlstrøm
Researcher at Oslo University Hospital
Publications - 91
Citations - 3708
Lasse Pihlstrøm is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Genome-wide association study & Parkinson's disease. The author has an hindex of 23, co-authored 77 publications receiving 2168 citations. Previous affiliations of Lasse Pihlstrøm include University of Oslo & University of Stavanger.
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Journal ArticleDOI
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Mike A. Nalls,Cornelis Blauwendraat,Costanza L. Vallerga,Karl Heilbron,Sara Bandres-Ciga,Diana Chang,Manuela Tan,Demis A. Kia,Alastair J. Noyce,Alastair J. Noyce,Angli Xue,Jose Bras,Jose Bras,Emily Young,Rainer von Coelln,Javier Simón-Sánchez,Javier Simón-Sánchez,Claudia Schulte,Claudia Schulte,Manu Sharma,Lynne Krohn,Lynne Krohn,Lasse Pihlstrøm,Ari Siitonen,Ari Siitonen,Hirotaka Iwaki,Hirotaka Iwaki,Leonard H,Faraz Faghri,Faraz Faghri,J. Raphael Gibbs,Dena G. Hernandez,Sonja W. Scholz,Sonja W. Scholz,Juan A. Botía,Juan A. Botía,Maria Martinez,Maria Martinez,Jean-Christophe Corvol,Suzanne Lesage,Joseph Jankovic,Lisa M. Shulman,Margaret Sutherland,Pentti J. Tienari,Kari Majamaa,Kari Majamaa,Mathias Toft,Mathias Toft,Ole A. Andreassen,Ole A. Andreassen,Tushar Bangale,Alexis Brice,Jian Yang,Ziv Gan-Or,Ziv Gan-Or,Thomas Gasser,Thomas Gasser,Peter Heutink,Peter Heutink,Joshua M. Shulman,Nicholas W. Wood,David A. Hinds,John Hardy,Huw R. Morris,Jacob Gratten,Peter M. Visscher,Robert R. Graham,Andrew B. Singleton,Astrid Adarmes-Gómez,Miquel Aguilar,Akbota Aitkulova,Vadim Akhmetzhanov,Roy N. Alcalay,Ignacio Alvarez,Victoria Alvarez,Francisco J. Barrero,Jesús Alberto Bergareche Yarza,Inmaculada Bernal-Bernal,Kimberley Billingsley,Marta Blazquez,Marta Bonilla-Toribio,María Teresa Boungiorno,Kathrin Brockmann,Vivien J. Bubb,Dolores Buiza-Rueda,Ana Cámara,Fátima Carrillo,Mario Carrión-Claro,Debora Cerdan,Viorica Chelban,Jordi Clarimón,Carl E Clarke,Yaroslau Compta,Mark R. Cookson,David Craig,Fabrice Danjou,Monica Diez-Fairen,Oriol Dols-Icardo,Jacinto Duarte,Raquel Duran,Francisco Escamilla-Sevilla,Valentina Escott-Price,Mario Ezquerra,Cici Feliz,Manel Fernández,Rubén Fernández-Santiago,Steven Finkbeiner,Thomas Foltynie,Ciara Garcia,Pedro J. Garcia-Ruiz,Maria Jose Gomez Heredia,Pilar Gómez-Garre,Manuel Menéndez González,Isabel González-Aramburu,Sebastian Guelfi,Rita Guerreiro,John Hardy,Sharon Hassin-Baer,Janet Hoenicka,Peter Holmans,Henry Houlden,Jon Infante,Silvia Jesús,Adriano Jimenez-Escrig,Gulnaz Kaishybayeva,Rauan Kaiyrzhanov,Altynay Karimova,Kerri J. Kinghorn,Sulev Kõks,Jaime Kulisevsky,Miguel A. Labrador-Espinosa,Hampton L. Leonard,Patrick A. Lewis,Jose Lopez-Sendon,Ruth C. Lovering,Steven J. Lubbe,Codrin Lungu,Daniel Macias,Claudia Manzoni,Juan Marín,Johan Marinus,María José Martí,Irene Martínez Torres,Juan Carlos Martínez-Castrillo,Marina Mata,Niccolo E. Mencacci,Carlota Méndez-del-Barrio,Ben Middlehurst,Adolfo Mínguez,Pablo Mir,Kin Y. Mok,Esteban Muñoz,Derek P. Narendra,Oluwadamilola O. Ojo,Njideka U Okubadejo,Ana Gorostidi Pagola,Pau Pastor,Francisco Perez Errazquin,Teresa Periñán-Tocino,Helene Plun-Favreau,John P. Quinn,Lea R'Bibo,Xylena Reed,Elisabet Mondragon Rezola,Mie Rizig,Patrizia Rizzu,Laurie Robak,Antonio Sanchez Rodriguez,Guy A. Rouleau,Javier Ruiz-Martínez,Clara Ruz,Mina Ryten,Dinara Sadykova,Sebastian R Schreglmann,Chingiz Shashkin,María Sierra,Esther Suarez-Sanmartin,Pille Taba,Cesar Tabernero,Manuela X Tan,Juan Pablo Tartari,Cristina Tejera-Parrado,Eduard Tolosa,Daniah Trabzuni,Francesc Valldeoriola,Jacobus J. van Hilten,Kendall Van Keuren-Jensen,Laura Vargas-González,Lydia Vela,Francisco Vives,Nigel Williams,Nazira Zharkinbekova,Zharkyn Zharmukhanov,Elena Zholdybayeva,Alexander Zimprich,Pauli Ylikotila,Stephen G. Reich,Joseph M. Savitt,Michelle Agee,Babak Alipanahi,Adam Auton,Robert K. Bell,Katarzyna Bryc,Sarah L. Elson,Pierre Fontanillas,Nicholas A. Furlotte,Karen E. Huber,Barry W. Hicks,Ethan M. Jewett,Yunxuan Jiang,Aaron Kleinman,Keng-Han Lin,Nadia K. Litterman,Jennifer C. McCreight,Matthew H. McIntyre,Kimberly F. McManus,Joanna L. Mountain,Elizabeth S. Noblin,Carrie A.M. Northover,Steven J. Pitts,G. David Poznik,J. Fah Sathirapongsasuti,Janie F. Shelton,Suyash Shringarpure,Chao Tian,Joyce Y. Tung,Vladimir Vacic,Xin Wang,Catherine H. Wilson,Tim J. Anderson,Steven R. Bentley,John C. Dalrymple-Alford,Javed Fowdar,Glenda M. Halliday,Anjali K. Henders,Ian B. Hickie,Irfahan Kassam,Martin A. Kennedy,John B.J. Kwok,Simon J.G. Lewis,George D. Mellick,Grant W. Montgomery,John F. Pearson,Toni L. Pitcher,Julia Sidorenko,Peter A. Silburn,Leanne Wallace,Naomi R. Wray,Futao Zhang +248 more
TL;DR: These data provide the most comprehensive survey of genetic risk within Parkinson's disease to date, providing a biological context for these risk factors, and showing that a considerable genetic component of this disease remains unidentified.
Journal ArticleDOI
Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.
Cornelis Blauwendraat,Karl Heilbron,Costanza L. Vallerga,Sara Bandres-Ciga,Rainer von Coelln,Lasse Pihlstrøm,Javier Simón-Sánchez,Javier Simón-Sánchez,Claudia Schulte,Claudia Schulte,Manu Sharma,Lynne Krohn,Lynne Krohn,Ari Siitonen,Ari Siitonen,Hirotaka Iwaki,Hirotaka Iwaki,Hampton L. Leonard,Alastair J. Noyce,Alastair J. Noyce,Manuela Tan,J. Raphael Gibbs,Dena G. Hernandez,Sonja W. Scholz,Joseph Jankovic,Lisa M. Shulman,Suzanne Lesage,Jean-Christophe Corvol,Alexis Brice,Jacobus J. van Hilten,Johan Marinus,Johanna Eerola-Rautio,Pentti J. Tienari,Kari Majamaa,Mathias Toft,Mathias Toft,Donald G. Grosset,Donald G. Grosset,Thomas Gasser,Peter Heutink,Peter Heutink,Joshua M. Shulman,Joshua M. Shulman,N Wood,N Wood,John Hardy,Huw R. Morris,David A. Hinds,Jacob Gratten,Peter M. Visscher,Peter M. Visscher,Ziv Gan-Or,Mike A. Nalls,Mike A. Nalls,Andrew B. Singleton +54 more
TL;DR: The genetic determinants of PD age at onset are largely unknown and increasing evidence supports an extensive and complex genetic contribution to PD.
Journal ArticleDOI
The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease.
Christina M. Lill,Christina M. Lill,Aina Rengmark,Lasse Pihlstrøm,Isabella Fogh,Aleksey Shatunov,Patrick M. A. Sleiman,Patrick M. A. Sleiman,Li-San Wang,Tian Liu,Christina F. Lassen,Esther Meissner,Panos Alexopoulos,Andrea Calvo,Adriano Chiò,Nil Dizdar,Frank Faltraco,Lars Forsgren,Julia Kirchheiner,Alexander Kurz,Jan Petter Larsen,Maria Liebsch,Jan Linder,Karen E. Morrison,Karen E. Morrison,Hans Nissbrandt,Markus Otto,Jens Pahnke,Jens Pahnke,Amanda Partch,Gabriella Restagno,Dan Rujescu,Cathrin Schnack,Christopher Shaw,Pamela J. Shaw,Hayrettin Tumani,Ole-Bjørn Tysnes,Ole-Bjørn Tysnes,Otto Valladares,Vincenzo Silani,Leonard H. van den Berg,Wouter van Rheenen,Jan H. Veldink,Ulman Lindenberger,Elisabeth Steinhagen-Thiessen,Stefan J. Teipel,Stefan J. Teipel,Robert Perneczky,Robert Perneczky,Hakon Hakonarson,Hakon Hakonarson,Harald Hampel,Harald Hampel,Christine A. F. von Arnim,Jørgen H. Olsen,Vivianna M. Van Deerlin,Ammar Al-Chalabi,Mathias Toft,Beate Ritz,Lars Bertram,Lars Bertram,Lars Bertram +61 more
TL;DR: The data show that rs75932628 is highly significantly associated with the risk of AD across 24,086 AD cases and 148,993 controls of European descent and carriers of the rs75 932628 risk allele showed significantly increased levels of CSF‐total‐tau but not Aβ42 suggesting that TREM2's role in AD may involve tau dysfunction.
Journal ArticleDOI
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia
Cornelis Blauwendraat,Xylena Reed,Lynne Krohn,Lynne Krohn,Karl Heilbron,Sara Bandres-Ciga,Manuela Tan,Raphael Gibbs,Dena G. Hernandez,Ravindran Kumaran,Rebekah G. Langston,Luis Bonet-Ponce,Roy N. Alcalay,Sharon Hassin-Baer,Lior Greenbaum,Lior Greenbaum,Hirotaka Iwaki,Hampton L. Leonard,Francis P. Grenn,Jennifer A. Ruskey,Jennifer A. Ruskey,Marya S. Sabir,Sarah A. Ahmed,Mary B. Makarious,Lasse Pihlstrøm,Mathias Toft,Jacobus J. van Hilten,Johan Marinus,Claudia Schulte,Claudia Schulte,Kathrin Brockmann,Kathrin Brockmann,Manu Sharma,Ari Siitonen,Ari Siitonen,Kari Majamaa,Kari Majamaa,Johanna Eerola-Rautio,Pentti J. Tienari,Alexander Pantelyat,Argye E. Hillis,Ted M. Dawson,Liana S. Rosenthal,Marilyn Albert,Susan M. Resnick,Luigi Ferrucci,Christopher Morris,Olga Pletnikova,Juan C. Troncoso,Donald G. Grosset,Suzanne Lesage,Jean-Christophe Corvol,Alexis Brice,Alastair J. Noyce,Alastair J. Noyce,Eliezer Masliah,Nicholas W. Wood,John Hardy,Lisa M. Shulman,Joseph Jankovic,Joshua M. Shulman,Joshua M. Shulman,Peter Heutink,Peter Heutink,Thomas Gasser,Thomas Gasser,Paul Cannon,Sonja W. Scholz,Sonja W. Scholz,Huw R. Morris,Mark R. Cookson,Mike A. Nalls,Ziv Gan-Or,Ziv Gan-Or,Andrew B. Singleton +74 more
TL;DR: The overall Parkinson's disease genetic risk score modifies risk for disease and decreases age at onset in carriers of GBA variants, and common variability at genes implicated in lysosomal function exerts the largest effect on GBA associatedrisk for disease.
Posted ContentDOI
Expanding Parkinson’s disease genetics: novel risk loci, genomic context, causal insights and heritable risk
Mike A. Nalls,Cornelis Blauwendraat,Costanza L. Vallerga,Karl Heilbron,Sara Bandres-Ciga,Diana Chang,Manuela Tan,Demis A. Kia,Alastair J. Noyce,Alastair J. Noyce,Angli Xue,Jose Bras,Jose Bras,Emily Young,Rainer von Coelln,Javier Simón-Sánchez,Javier Simón-Sánchez,Claudia Schulte,Claudia Schulte,Manu Sharma,Lynne Krohn,Lynne Krohn,Lasse Pihlstrøm,Ari Siitonen,Ari Siitonen,Hirotaka Iwaki,Hampton L. Leonard,Faraz Faghri,J. Raphael Gibbs,Dena G. Hernandez,Sonja W. Scholz,Sonja W. Scholz,Juan A. Botía,Juan A. Botía,Maria Martinez,Jean-Christophe Corvol,Suzanne Lesage,Joseph Jankovic,Lisa M. Shulman,Margaret Sutherland,Pentti J. Tienari,Kari Majamaa,Kari Majamaa,Mathias Toft,Mathias Toft,Ole A. Andreassen,Ole A. Andreassen,Tushar Bangale,Alexis Brice,Jian Yang,Ziv Gan-Or,Ziv Gan-Or,Thomas Gasser,Thomas Gasser,Peter Heutink,Peter Heutink,Joshua M. Shulman,Joshua M. Shulman,N Wood,David A. Hinds,John Hardy,Huw R. Morris,Jacob Gratten,Peter M. Visscher,Robert R. Graham,Andrew B. Singleton +65 more
TL;DR: These data provide the most comprehensive understanding of the genetic architecture of PD to date by revealing many additional PD risk loci, providing a biological context for these risk factors, and demonstrating that a considerable genetic component of this disease remains unidentified.