Laszlo Revesz

TL;DR: The design, synthesis, and the biological evaluation of 2-benzamido-pyrimidines as novel IKK inhibitors are described and compounds 16 and 24 are identified as good inhibitors of IKK2 with IC(50) values of 40 and 25 nM, respectively.

TL;DR: It is suggested that CCR1 antagonists can provide antimetastatic therapies for patients with disseminated colon cancer in the liver because of their role in tumor invasion and metastasis.

TL;DR: Findings show in vitro and in vivo in mammals that CD95 and the TNF-alpha receptor share a distal proteolytic apoptosis signal.

TL;DR: Time course experiments showed that the 10-kDa subunit was released from the 45-k Da precursor before the 20-k da subunit, implying that the N-terminal portion of the precursor is released last and may play a regulatory role.

TL;DR: Oral treatment with the CCR1 antagonist BL5923 is identified as a potential therapy for late-stage diabetic nephropathy and identifies a previously unrecognized role for interstitial macrophages for tubulointerstitial injury, loss of peritubular microvasculature, interstitial inflammation, and fibrosis in type 2 diabetic db/db mice.