L
Laura Guasch
Researcher at National Institutes of Health
Publications - 25
Citations - 787
Laura Guasch is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virtual screening & Quantitative structure–activity relationship. The author has an hindex of 16, co-authored 24 publications receiving 676 citations. Previous affiliations of Laura Guasch include Rovira i Virgili University.
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DecoyFinder: an easy-to-use python GUI application for building target-specific decoy sets
Adrià Cereto-Massagué,Laura Guasch,Cristina Valls,Miquel Mulero,Gerard Pujadas,Santiago Garcia-Vallvé +5 more
TL;DR: To the best of the knowledge, DecoyFinder is the first application designed to build target-specific decoy sets, and it is provided as a validation on 10 DUD targets as Supplementary Table S1.
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Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Ligand Choreography: Newcomers Take the Stage.
Santiago Garcia-Vallvé,Laura Guasch,Sarah Tomás-Hernández,Josep M. del Bas,Vincent Ollendorff,Lluís Arola,Gerard Pujadas,Miquel Mulero +7 more
TL;DR: Facing the new mechanistic scenario proposed for these compounds is essential for resolving the paradoxes among their agonistic function, antidi diabetic activities, and side effects and should allow the rational development of better and safer PPARγ-mediated antidiabetic drugs.
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Metabolic Regulation of Histone Acetyltransferases by Endogenous Acyl-CoA Cofactors
TL;DR: A novel chemoproteomic probe is used to define the metabolic regulation of lysine acetyltransferase (KAT) enzymes and identifies a previously unreported interaction between palmitoyl coenzyme A (palMIToyl-CoA) and KAT enzymes, which implicate fatty acyl-CoAs as endogenous regulators of histone acetylation.
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Structural insights for the design of new PPARgamma partial agonists with high binding affinity and low transactivation activity
Laura Guasch,Esther Sala,Cristina Valls,Mayte Blay,Miquel Mulero,Lluís Arola,Gerard Pujadas,Santiago Garcia-Vallvé +7 more
TL;DR: The results suggest that effective partial agonists should have a hydrophobic moiety and an acceptor site with an appropriate conformation to interact with arm II and establish a hydrogen bond with Ser342 or an equivalent residue at arm III.
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Characterizing the Covalent Targets of a Small Molecule Inhibitor of the Lysine Acetyltransferase P300
Jonathan H. Shrimp,Alexander W. Sorum,Julie M. Garlick,Laura Guasch,Marc C. Nicklaus,Jordan L. Meier +5 more
TL;DR: Findings should enable a more precise interpretation of studies utilizing C646 as a chemical probe of KAT activity and suggest that an underappreciated liability of electrophile-containing inhibitors is a reduction in their cellular potency due to consumption by abundant protein and metabolite thiol sinks.