L
Laura Maggi
Researcher at Sapienza University of Rome
Publications - 49
Citations - 5367
Laura Maggi is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Hippocampal formation & Microglia. The author has an hindex of 24, co-authored 45 publications receiving 4299 citations. Previous affiliations of Laura Maggi include International School for Advanced Studies & Pasteur Institute.
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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Rosa C. Paolicelli,Giulia Bolasco,Francesca Pagani,Laura Maggi,Maria Scianni,Patrizia Panzanelli,Maurizio Giustetto,Tiago Ferreira,Eva Guiducci,Laura Dumas,Davide Ragozzino,Cornelius Gross +11 more
TL;DR: It is shown that microglia actively engulf synaptic material and play a major role in synaptic pruning during postnatal development in mice and this work suggests that deficits in microglian function may contribute to synaptic abnormalities seen in some neurodevelopmental disorders.
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Dark microglia: A new phenotype predominantly associated with pathological states
Kanchan Bisht,Kaushik P. Sharma,Cynthia Lecours,Maria Gabriela Sánchez,Hassan El Hajj,Giampaolo Milior,Adrian Olmos-Alonso,Diego Gomez-Nicola,Giamal N. Luheshi,Luc Vallières,Igor Branchi,Laura Maggi,Cristina Limatola,Oleg Butovsky,Marie-Ève Tremblay +14 more
TL;DR: Findings suggest that dark microglia, a new phenotype that is rarely present under steady state conditions, but becomes abundant during chronic stress, aging, fractalkine signaling deficiency, and Alzheimer's disease pathology, could play a significant role in the pathological remodeling of neuronal circuits, especially at synapses.
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Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress
Giampaolo Milior,Cynthia Lecours,Louis Samson,Kanchan Bisht,S. Poggini,Francesca Pagani,Cristina Deflorio,Clotilde Lauro,Silvia Alboni,Cristina Limatola,Igor Branchi,Marie-Ève Tremblay,Laura Maggi +12 more
TL;DR: Hampering neuron-microglia communication via the CX3CR1-CX3CL1 pathway prevents the effects of chronic unpredictable stress on microglial function, short- and long-term neuronal plasticity and depressive-like behavior.
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CX(3)CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment.
TL;DR: It is found that CX3CR1 deficiency increases hippocampal plasticity and spatial memory, blunting the potentiating effects of EE, indicating that Cx3CL1/CX3 CR1-mediated signaling is crucial for a normal experience-dependent modulation of hippocampal functions.
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Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment
Silvia Alboni,R. M. van Dijk,S. Poggini,Giampaolo Milior,M L Perrotta,T. Drenth,Nicoletta Brunello,David P. Wolfer,David P. Wolfer,Cristina Limatola,Irmgard Amrein,Francesca Cirulli,Laura Maggi,Igor Branchi,Igor Branchi +14 more
TL;DR: The hypothesis positing that SSRIs may not affect mood per se but, by enhancing neural plasticity, render the individual more susceptible to the influence of the environment is explored, suggesting that SSRI administration in a favorable environment promotes a reduction of symptoms, whereas in a stressful environment leads to a worse prognosis.