Laura Schreiner

TL;DR: A monodisperse and multifunctional carrier system, synthesized by solid phase supported chemistry, for siRNA delivery in vitro and in vivo showed stability in vivo, receptor-specific cell targeting, and silencing of the EG5 gene in receptor-positive tumors.

TL;DR: The results indicate that archazolid effectively decreases metastatic dissemination of breast tumors by impairing the trafficking and spatially restricted activation of EGFR and Rho-GTPase Rac1, which are pivotal for directed movement of cells.

TL;DR: Nine sequence-defined, polycationic oligomers were synthesized containing motifs of three consecutive tyrosines (Y3) as stabilizing components for pDNA and siRNA polyplex assembly, which resulted in significantly reduced tumor growth compared to animal treated with control si RNA polyplexes.

TL;DR: V-ATPase inhibition is not only an interesting option to reduce cancer metastasis, but also to better understand anoikis resistance and to find choices to fight against it.

TL;DR: Results show that inhibition of V‐ATPase by archazolid reduces the activity of prometastatic proteases like cathepsin B in vitro and in vivo.