L
Laure Sapey-Triomphe
Researcher at Claude Bernard University Lyon 1
Publications - 4
Citations - 131
Laure Sapey-Triomphe is an academic researcher from Claude Bernard University Lyon 1. The author has contributed to research in topics: Male pronucleus & Chromatin. The author has an hindex of 4, co-authored 4 publications receiving 104 citations.
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Drosophila Yemanuclein and HIRA Cooperate for De Novo Assembly of H3.3-Containing Nucleosomes in the Male Pronucleus
Guillermo A. Orsi,Ahmed Algazeery,Régis E. Meyer,Michèle Capri,Laure Sapey-Triomphe,Béatrice Horard,Henri Gruffat,Pierre Couble,Ounissa Aït-Ahmed,Benjamin Loppin +9 more
TL;DR: Yemanuclein (YEM), the Drosophila member of the Hpc2/Ubinuclein family, is essential for histone deposition in the male pronucleus and the alternative ATRX/XNP-dependent H3.3 deposition pathway is shown to be not involved in paternal chromatin assembly, underlining the specific implication of the HIRA/YEM complex for this essential step of zygote formation.
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The Spartan Ortholog Maternal Haploid Is Required for Paternal Chromosome Integrity in the Drosophila Zygote
Laetitia Delabaere,Guillermo A. Orsi,Laure Sapey-Triomphe,Béatrice Horard,Pierre Couble,Benjamin Loppin +5 more
TL;DR: It is shown that MH is the fly ortholog of the recently identified human DVC1/Spartan protein, a conserved regulator of DNA damage tolerance, and is involved in the resistance to UV radiation and recruits the p97/TER94 segregase to stalled DNA replication forks in somatic cells.
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Drosophila protamine-like Mst35Ba and Mst35Bb are required for proper sperm nuclear morphology but are dispensable for male fertility.
Samantha Tirmarche,Shuhei Kimura,Laure Sapey-Triomphe,William J. Sullivan,Frédéric Landmann,Benjamin Loppin +5 more
TL;DR: Drosophila males homozygous for a genomic deletion covering several genes including the protamine-like genes Mst35Ba/b are surprisingly fertile, and this work precisely deleted the Mst 35B locus by homologous recombination, and it is confirmed the dispensability of Mst34B for fertility.
Journal ArticleDOI
ASF1 is required to load histones on the HIRA complex in preparation of paternal chromatin assembly at fertilization
TL;DR: It is concluded that ASF1 is critically required to load H3.3–H4 dimers on the HIRA complex prior to histone deposition on paternal DNA, which could optimize the rapid assembly of paternal chromatin within the gigantic volume of the egg cell.