Lauren M. Aleksunes

TL;DR: A comprehensive overview of transporters of the solute carrier family (SLC) is provided with regard to tissue distribution, subcellular localization, and substrate preferences.

TL;DR: The activation of the Nrf2 regulatory pathway stimulates the coordinated induction of hepatic Mrps in mice treated with oltipraz and butylated hydroxyanisole.

TL;DR: Research of Nrf2 has opened up new opportunities in understanding how antioxidant defense pathways are regulated, how oxidative stress contributes to disease progression and may serve as a novel target for designing therapies to prevent and treat diseases in which oxidative stress is implicated.

TL;DR: The present study demonstrates the novel finding that Nrf2 is required for TCDD induction of classical AhR battery genes Nqo1, Ugt1a6, and Gsta1, as well as most Ugt and Gst isoforms in livers of mice.

TL;DR: Identification of genes encoding drug-metabolizing enzymes and transporters altered by chemical activators in a transcription factor-dependent manner and Pharmacological activation of each transcription factor leads to mRNA induction of drug metabolic and transport genes in livers of male and female wild-type mice reveal transcription factor specificity and overlap in regulating hepatic drug disposition genes by chemical activation.