L
Laurence Briant
Researcher at University of Montpellier
Publications - 83
Citations - 5354
Laurence Briant is an academic researcher from University of Montpellier. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 34, co-authored 80 publications receiving 4893 citations. Previous affiliations of Laurence Briant include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
Biology of Zika Virus Infection in Human Skin Cells
Rodolphe Hamel,Ophélie Dejarnac,Sineewanlaya Wichit,Peeraya Ekchariyawat,Aymeric Neyret,Natthanej Luplertlop,Manuel Perera-Lecoin,Pornapat Surasombatpattana,Loïc Talignani,Frédéric Thomas,Van-Mai Cao-Lormeau,Valérie Choumet,Laurence Briant,Philippe Desprès,Ali Amara,Hans Yssel,Dorothée Missé +16 more
TL;DR: It is shown that human dermal fibroblasts, epidermal keratinocytes, and immature dendritic cells are permissive to the most recent ZikV isolate, responsible for the epidemic in French Polynesia, and a major role is shown for the phosphatidylserine receptor AXL as a ZIKV entry receptor and for cellular autophagy in enhancing ZIKv replication in permissive cells.
Journal ArticleDOI
Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-a and TNF-0 by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus
Flemming Pociot,Laurence Briant,Cornelis Jongeneel,J. Mølvig,Helle Worsaae,Michel Abbal,Mogens Thomsen,Jørn Nerup,Anne Cambon-Thomsen +8 more
TL;DR: In a group of DR3/DR4 heterozygous patients with insulin‐dependent diabetes mellitus (IDDM), the frequency of the TNFa2 allele was higher than in HLA‐DR matched controls, whereas theTNFa6 allele was more frequent in control individuals.
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Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility
C Julier,R N Hyer,J Davies,F Merlin,P Soularue,Laurence Briant,G Cathelineau,I. Deschamps,Jerome I. Rotter,Philippe Froguel +9 more
TL;DR: The results strongly support the existence of a gene or genes affecting HLA-DR4 IDDM susceptibility which is located in a 19-kilobase region of INS-IGF2, and suggest new ways to map susceptibility loci in other common diseases.
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Replication cycle of chikungunya: A re-emerging arbovirus
Maxime Solignat,Stephen Higgs,Laurence Briant,Laurence Briant,Christian Devaux,Christian Devaux +5 more
TL;DR: This paper summarizes the current knowledge of CHIKV genomic organization, cell tropism, and the virus replication cycle, and evaluates the possibility to predict its future evolution, in order to anticipate future epidemics and reduce the incidence by development and application of vaccination and antiviral therapy.
Journal ArticleDOI
Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes.
Cornelis Jongeneel,Laurence Briant,Irina A. Udalova,André Sevin,Sergei A. Nedospasov,Anne Cambon-Thomsen +5 more
TL;DR: Three polymorphic microsatellites within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies.