L
Laurence Florens
Researcher at Stowers Institute for Medical Research
Publications - 306
Citations - 30289
Laurence Florens is an academic researcher from Stowers Institute for Medical Research. The author has contributed to research in topics: Chromatin & RNA polymerase II. The author has an hindex of 83, co-authored 293 publications receiving 27313 citations. Previous affiliations of Laurence Florens include University of Oklahoma Health Sciences Center & Imperial College London.
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Journal ArticleDOI
A proteomic view of the Plasmodium falciparum life cycle
Laurence Florens,Michael P. Washburn,J. Dale Raine,Robert M. Anthony,Munira Grainger,J. David Haynes,J. David Haynes,J. Kathleen Moch,Nemone Muster,John B. Sacci,John B. Sacci,David L. Tabb,David L. Tabb,Adam A. Witney,Adam A. Witney,Dirk Wolters,Dirk Wolters,Yimin Wu,Malcolm J. Gardner,Anthony A. Holder,Robert E. Sinden,John R. Yates,John R. Yates,Daniel J. Carucci +23 more
TL;DR: A high-throughput proteomics approach was applied to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite.
Journal ArticleDOI
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription.
Michael J. Carrozza,Bing Li,Laurence Florens,Tamaki Suganuma,Selene K. Swanson,Kenneth K. Lee,Wei-Jong Shia,Scott Anderson,John R. Yates,Michael P. Washburn,Jerry L. Workman +10 more
TL;DR: Data indicate that Pol II-associated Set2 methylates H3 providing a transcriptional memory which signals for deacetylation of ORFs by Rpd3S, which erases transcription elongation-associated acetylation to suppress intragenic transcription initiation.
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Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
Kasia Hrecka,Caili Hao,Magda Gierszewska,Selene K. Swanson,Malgorzata Kesik-Brodacka,Smita Srivastava,Laurence Florens,Michael P. Washburn,Michael P. Washburn,Jacek Skowronski,Jacek Skowronski +10 more
TL;DR: These findings show that macrophages are defended from HIV-1 infection by a mechanism that prevents an unwanted interferon response triggered by self nucleic acids, and uncover an intricate relationship between innate immune mechanisms that control response to self and to retroviral pathogens.
Journal ArticleDOI
Statistical analysis of membrane proteome expression changes in Saccharomyces cerevisiae.
Boris Zybailov,Amber L. Mosley,Mihaela E. Sardiu,Michael K. Coleman,Laurence Florens,Michael P. Washburn +5 more
TL;DR: An approach for analyzing shotgun proteomics datasets based on the normalized spectral abundance factor that can be used for quantitative proteomics analysis is devised and amino acid transporters were among the 14 membrane proteins that were significantly upregulated in cells grown in minimal media.
Journal ArticleDOI
A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses
Neil Hall,Marianna Karras,J. Dale Raine,Jane M. Carlton,Jane M. Carlton,Jane M. Carlton,Taco W. A. Kooij,Matthew Berriman,Laurence Florens,Christoph S. Janssen,Arnab Pain,Georges K. Christophides,Keith D. James,Kim Rutherford,Barbara Harris,David Harris,Carol Churcher,Michael A. Quail,Doug Ormond,Jon Doggett,Holly E. Trueman,Jacqui Mendoza,Shelby L. Bidwell,Marie Adele Rajandream,Daniel J. Carucci,John R. Yates,Fotis C. Kafatos,Chris J. Janse,Bart Barrell,C. Michael R. Turner,Andrew P. Waters,Robert E. Sinden +31 more
TL;DR: It is observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3′ untranslated region motif is implicated in this process.