Laurent Heutte

Bio: Laurent Heutte is an academic researcher from University of Rouen. The author has contributed to research in topics: Handwriting recognition & Random forest. The author has an hindex of 28, co-authored 133 publications receiving 3944 citations. Previous affiliations of Laurent Heutte include Matra & Intelligence and National Security Alliance.

A Dataset for Breast Cancer Histopathological Image Classification

Abstract: Today, medical image analysis papers require solid experiments to prove the usefulness of proposed methods. However, experiments are often performed on data selected by the researchers, which may come from different institutions, scanners, and populations. Different evaluation measures may be used, making it difficult to compare the methods. In this paper, we introduce a dataset of 7909 breast cancer histopathology images acquired on 82 patients, which is now publicly available from http://web.inf.ufpr.br/vri/breast-cancer-database . The dataset includes both benign and malignant images. The task associated with this dataset is the automated classification of these images in two classes, which would be a valuable computer-aided diagnosis tool for the clinician. In order to assess the difficulty of this task, we show some preliminary results obtained with state-of-the-art image classification systems. The accuracy ranges from 80% to 85%, showing room for improvement is left. By providing this dataset and a standardized evaluation protocol to the scientific community, we hope to gather researchers in both the medical and the machine learning field to advance toward this clinical application.

Breast cancer histopathological image classification using Convolutional Neural Networks

Abstract: The performance of most conventional classification systems relies on appropriate data representation and much of the efforts are dedicated to feature engineering, a difficult and time-consuming process that uses prior expert domain knowledge of the data to create useful features. On the other hand, deep learning can extract and organize the discriminative information from the data, not requiring the design of feature extractors by a domain expert. Convolutional Neural Networks (CNNs) are a particular type of deep, feedforward network that have gained attention from research community and industry, achieving empirical successes in tasks such as speech recognition, signal processing, object recognition, natural language processing and transfer learning. In this paper, we conduct some preliminary experiments using the deep learning approach to classify breast cancer histopathological images from BreaKHis, a publicly dataset available at http://web.inf.ufpr.br/vri/breast-cancer-database. We propose a method based on the extraction of image patches for training the CNN and the combination of these patches for final classification. This method aims to allow using the high-resolution histopathological images from BreaKHis as input to existing CNN, avoiding adaptations of the model that can lead to a more complex and computationally costly architecture. The CNN performance is better when compared to previously reported results obtained by other machine learning models trained with hand-crafted textural descriptors. Finally, we also investigate the combination of different CNNs using simple fusion rules, achieving some improvement in recognition rates.

Multiple instance learning for histopathological breast cancer image classification

Abstract: Histopathological images are the gold standard for breast cancer diagnosis. During examination several dozens of them are acquired for a single patient. Conventional, image-based classification systems make the assumption that all the patient’s images have the same label as the patient, which is rarely verified in practice since labeling the data is expensive. We propose a weakly supervised learning framework and investigate the relevance of Multiple Instance Learning (MIL) for computer-aided diagnosis of breast cancer patients, based on the analysis of histopathological images. Multiple instance learning consists in organizing instances (images) into bags (patients), without the need to label all the instances. We compare several state-of-the-art MIL methods including the pioneering ones (APR, Diverse Density, MI-SVM, citation-kNN), and more recent ones such as a non parametric method and a deep learning based approach (MIL-CNN). The experiments are conducted on the public BreaKHis dataset which contains about 8000 microscopic biopsy images of benign and malignant breast tumors, originating from 82 patients. Among the MIL methods the non-parametric approach has the best overall results, and in some cases allows to obtain classification rates never reached by conventional (single instance) classification frameworks. The comparison between MIL and single instance classification reveals the relevance of the MIL paradigm for the task at hand. In particular, the MIL allows to obtain comparable or better results than conventional (single instance) classification without the need to label all the images.

Deep features for breast cancer histopathological image classification

Abstract: Breast cancer (BC) is a deadly disease, killing millions of people every year. Developing automated malignant BC detection system applied on patient's imagery can help dealing with this problem more efficiently, making diagnosis more scalable and less prone to errors. Not less importantly, such kind of research can be extended to other types of cancer, making even more impact to help saving lives. Recent results on BC recognition show that Convolution Neural Networks (CNN) can achieve higher recognition rates than hand-crafted feature descriptors, but the price to pay is an increase in complexity to develop the system, requiring longer training time and specific expertise to fine-tune the architecture of the CNN. DeCAF (or deep) features consist of an in-between solution it is based on reusing a previously trained CNN only as feature vectors, which is then used as input for a classifier trained only for the new classification task. In the light of this, we present an evaluation of DeCaf features for BC recognition, in order to better understand how they compare to the other approaches. The experimental evaluation shows that these features can be a viable alternative to fast development of high-accuracy BC recognition systems, generally achieving better results than traditional hand-crafted textural descriptors and outperforming task-specific CNNs in some cases.

Machine learning

Abstract: Machine Learning is the study of methods for programming computers to learn. Computers are applied to a wide range of tasks, and for most of these it is relatively easy for programmers to design and implement the necessary software. However, there are many tasks for which this is difficult or impossible. These can be divided into four general categories. First, there are problems for which there exist no human experts. For example, in modern automated manufacturing facilities, there is a need to predict machine failures before they occur by analyzing sensor readings. Because the machines are new, there are no human experts who can be interviewed by a programmer to provide the knowledge necessary to build a computer system. A machine learning system can study recorded data and subsequent machine failures and learn prediction rules. Second, there are problems where human experts exist, but where they are unable to explain their expertise. This is the case in many perceptual tasks, such as speech recognition, hand-writing recognition, and natural language understanding. Virtually all humans exhibit expert-level abilities on these tasks, but none of them can describe the detailed steps that they follow as they perform them. Fortunately, humans can provide machines with examples of the inputs and correct outputs for these tasks, so machine learning algorithms can learn to map the inputs to the outputs. Third, there are problems where phenomena are changing rapidly. In finance, for example, people would like to predict the future behavior of the stock market, of consumer purchases, or of exchange rates. These behaviors change frequently, so that even if a programmer could construct a good predictive computer program, it would need to be rewritten frequently. A learning program can relieve the programmer of this burden by constantly modifying and tuning a set of learned prediction rules. Fourth, there are applications that need to be customized for each computer user separately. Consider, for example, a program to filter unwanted electronic mail messages. Different users will need different filters. It is unreasonable to expect each user to program his or her own rules, and it is infeasible to provide every user with a software engineer to keep the rules up-to-date. A machine learning system can learn which mail messages the user rejects and maintain the filtering rules automatically. Machine learning addresses many of the same research questions as the fields of statistics, data mining, and psychology, but with differences of emphasis. Statistics focuses on understanding the phenomena that have generated the data, often with the goal of testing different hypotheses about those phenomena. Data mining seeks to find patterns in the data that are understandable by people. Psychological studies of human learning aspire to understand the mechanisms underlying the various learning behaviors exhibited by people (concept learning, skill acquisition, strategy change, etc.).

When is nearest neighbor meaningful

Abstract: We explore the effect of dimensionality on the nearest neighbor problem. We show that under a broad set of conditions (much broader than independent and identically distributed dimensions), as dimensionality increases, the distance to the nearest data point approaches the distance to the farthest data point. To provide a practical perspective, we present empirical results on both real and synthetic data sets that demonstrate that this effect can occur for as few as 10-15 dimensions. These results should not be interpreted to mean that high-dimensional indexing is never meaningful; we illustrate this point by identifying some high-dimensional workloads for which this effect does not occur. However, our results do emphasize that the methodology used almost universally in the database literature to evaluate high-dimensional indexing techniques is flawed, and should be modified. In particular, most such techniques proposed in the literature are not evaluated versus simple linear scan, and are evaluated over workloads for which nearest neighbor is not meaningful. Often, even the reported experiments, when analyzed carefully, show that linear scan would outperform the techniques being proposed on the workloads studied in high (10-15) dimensionality!.

IEEE transactions on pattern analysis and machine intelligence

Abstract: In the real world, a realistic setting for computer vision or multimedia recognition problems is that we have some classes containing lots of training data and many classes contain a small amount of training data. Therefore, how to use frequent classes to help learning rare classes for which it is harder to collect the training data is an open question. Learning with Shared Information is an emerging topic in machine learning, computer vision and multimedia analysis. There are different level of components that can be shared during concept modeling and machine learning stages, such as sharing generic object parts, sharing attributes, sharing transformations, sharing regularization parameters and sharing training examples, etc. Regarding the specific methods, multi-task learning, transfer learning and deep learning can be seen as using different strategies to share information. These learning with shared information methods are very effective in solving real-world large-scale problems. This special issue aims at gathering the recent advances in learning with shared information methods and their applications in computer vision and multimedia analysis. Both state-of-the-art works, as well as literature reviews, are welcome for submission. Papers addressing interesting real-world computer vision and multimedia applications are especially encouraged. Topics of interest include, but are not limited to: • Multi-task learning or transfer learning for large-scale computer vision and multimedia analysis • Deep learning for large-scale computer vision and multimedia analysis • Multi-modal approach for large-scale computer vision and multimedia analysis • Different sharing strategies, e.g., sharing generic object parts, sharing attributes, sharing transformations, sharing regularization parameters and sharing training examples, • Real-world computer vision and multimedia applications based on learning with shared information, e.g., event detection, object recognition, object detection, action recognition, human head pose estimation, object tracking, location-based services, semantic indexing. • New datasets and metrics to evaluate the benefit of the proposed sharing ability for the specific computer vision or multimedia problem. • Survey papers regarding the topic of learning with shared information. Authors who are unsure whether their planned submission is in scope may contact the guest editors prior to the submission deadline with an abstract, in order to receive feedback.