Lawrence J. Abraham

TL;DR: It is demonstrated that the region (−323 to −285) encompassing −308 in the TNF2 allele binds nuclear factors differently to the same region in the promoter of the more common TNF1 allele, suggesting that the −308 GA polymorphism may play a role in the altered TNF-α gene expression observed in individuals with the HLA Al, B8, DR3 haplotype.

TL;DR: To highlight the usefulness of this much-enlarged map of cis-regulated transcripts for the discovery of genes that influence complex traits in humans, as an example, high-density lipoprotein cholesterol concentration is selected as a phenotype of clinical importance and the cis- regulated vanin 1 (VNN1) gene is identified as harboring sequence variants that influence high- density lipop protein cholesterol concentrations.

TL;DR: The majority of the data support a direct role for the T NF2 ‐308 allele in the elevated TNF levels observed in TNF2 homozygotes and HLA‐A1, B8, DR3 individuals.

TL;DR: It is demonstrated that TNF signaling participates in the proliferation of oval cells during the preneoplastic phase of liver carcinogenesis and that loss of signaling through the TNF receptor type 1 reduces the incidence of tumor formation.

TL;DR: A number of Caucasoid MHC haplotypes that extend from HLA-B to DR and that have been conserved en bloc are described, which may be relevant to antigen presentation, autoimmune responses, and transplantation rejection.