抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Contents: Introduction: Differential Equations and Dynamical Systems.- An Introduction to Chaos: Four Examples.- Local Bifurcations.- Averaging and Perturbation from a Geometric Viewpoint.- Hyperbolic Sets, Sympolic Dynamics, and Strange Attractors.- Global Bifurcations.- Local Codimension Two Bifurcations of Flows.- Appendix: Suggestions for Further Reading. Postscript Added at Second Printing. Glossary. References. Index.

A Reflection on Nonlinear Oscillations, Dynamical Systems, and Bifurcations of Vector Fields

This introduction begins with a brief history of SHM technology development. Recent research has begun to recognise that a productive approach to the Structural Health Monitoring (SHM) problem is to regard it as one of statistical pattern recognition (SPR); a paradigm addressing the problem in such a way is described in detail herein as it forms the basis for the organisation of this book. In the process of providing the historical overview and summarising the SPR paradigm, the subsequent chapters in this book are cited in an effort to show how they fit into this overview of SHM. In the conclusions are stated a number of technical challenges that the authors believe must be addressed if SHM is to gain wider acceptance.

An introduction to structural health monitoring

Staff members at Los Alamos National Laboratory (LANL) produced a summary of the structural health monitoring literature in 1995. This presentation will summarize the outcome of an updated review covering the years 1996 2001. The updated review follows the LANL statistical pattern recognition paradigm for SHM, which addresses four topics: 1. Operational Evaluation; 2. Data Acquisition and Cleansing; 3. Feature Extraction; and 4. Statistical Modeling for Feature Discrimination. The literature has been reviewed based on how a particular study addresses these four topics. A significant observation from this review is that although there are many more SHM studies being reported, the investigators, in general, have not yet fully embraced the well-developed tools from statistical pattern recognition. As such, the discrimination procedures employed are often lacking the appropriate rigor necessary for this technology to evolve beyond demonstration problems carried out in laboratory setting.

A review of structural health monitoring literature 1996-2001

Past, present and future of nonlinear system identification in structural dynamics

Nonlinear Behavior of a Typical Airfoil Section with Control Surface Freeplay: a Numerical and Experimental Study

This 2007 book concerns the vibration and the stability of slender structural components. The loss of stability of structures is an important aspect of structural mechanics and is presented here in terms of dynamic behavior. A variety of structural components are analyzed with a view to predicting their response to various (primarily axial) loading conditions. A number of different techniques are presented, with experimental verification from the laboratory. Practical applications are widespread, ranging from cables to space structures. The book presents methods by which the combined effects of vibration and buckling on various structures can be assessed. Vibrations and buckling are usually treated separately, but in this book their influence on each other is examined together, with examples when a combined approach is necessary. The avoidance of instability is the primary goal of this material.

https://assets.cambridge.org/97805218/80428/frontmatter/9780521880428_frontmatter.pdf

Vibration of Axially-Loaded Structures

The paper presents analytical and numerical studies of the primary resonance and the 1/3 subharmonic resonance of a harmonically forced Duffing oscillator under state feedback control with a time delay. By using the method of multiple scales, the first order approximations of the resonances are derived and the effect of time delay on the resonances is analyzed. The concept of an equivalent damping related to the delay feedback is proposed and the appropriate choice of the feedback gains and the time delay is discussed from the viewpoint of vibration control. In order to numerically solve the problem of history dependence prior to the start of excitation, the concepts of the Poincare section and fixed points are generalized. Then, a modified shooting scheme associated with the path following technique is proposed to locate the periodic motion of the delayed system. The numerical results show the efficacy of the first order approximations of the resonances.

Resonances of a Harmonically Forced Duffing Oscillator with Time Delay State Feedback

Limit cycle behavior of an airfoil with a control surface

A novel feature extracted from a nonlinear time series is presented within the context of vibration-based damage detection in a system An eight-degree-of-freedom spring-mass-damper `structure' is considered with damage incurred by a stiffness degradation in one spring The system is excited with a chaotic input, and by tuning the Lyapunov exponents of the chaotic excitation to the dominant eigenvalue of the structure the dimensionality of the entire system is effectively controlled Both the input and output are viewed in state space as geometric objects, and the effect of the damage is shown to alter the geometric properties of the corresponding attractors at a local level, which may be captured in construction of the feature The utility of the feature is compared with that of a number of modal-based features and shown to be superior in resolving capability and in robustness

Lawrence N. Virgin

Papers

Nonlinear Behavior of a Typical Airfoil Section with Control Surface Freeplay: a Numerical and Experimental Study

Vibration of Axially-Loaded Structures

Resonances of a Harmonically Forced Duffing Oscillator with Time Delay State Feedback

Limit cycle behavior of an airfoil with a control surface

Vibration-based damage assessment utilizing state space geometry changes: local attractor variance ratio