L
Lawrence S.B. Goldstein
Researcher at University of California, San Diego
Publications - 227
Citations - 31385
Lawrence S.B. Goldstein is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Kinesin & Microtubule. The author has an hindex of 91, co-authored 226 publications receiving 29461 citations. Previous affiliations of Lawrence S.B. Goldstein include Scripps Health & University of South Florida.
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Journal ArticleDOI
Comparative Genomics of the Eukaryotes
Gerald M. Rubin,Mark Yandell,Jennifer R. Wortman,George L. Gabor,Miklos,Catherine R. Nelson,Iswar K. Hariharan,Mark E. Fortini,Peter W. Li,Rolf Apweiler,Wolfgang Fleischmann,J. Michael Cherry,Steven Henikoff,Marian P. Skupski,Sima Misra,Michael Ashburner,Ewan Birney,Mark S. Boguski,Thomas Brody,Peter Brokstein,Susan E. Celniker,Stephen A. Chervitz,David Coates,Anibal Cravchik,Andrei Gabrielian,Richard F. Galle,William M. Gelbart,Reed A. George,Lawrence S.B. Goldstein,Fangcheng Gong,Ping Guan,Nomi L. Harris,Bruce A. Hay,Roger A. Hoskins,Jiayin Li,Zhenya Li,Richard O. Hynes,Steven J.M. Jones,Peter M. Kuehl,Bruno Lemaitre,J. Troy Littleton,Deborah K. Morrison,Christopher J. Mungall,Patrick H. O'Farrell,Oxana K. Pickeral,Chris Shue,Leslie B. Vosshall,Jiong Zhang,Qi Zhao,Xiangqun H. Zheng,Fei Zhong,Wenyan Zhong,Richard A. Gibbs,J. Craig Venter,Mark Raymond Adams,Suzanna E. Lewis +55 more
TL;DR: The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
Journal ArticleDOI
Somatic coding mutations in human induced pluripotent stem cells
Athurva Gore,Zhe Li,Ho Lim Fung,Jessica E. Young,Suneet Agarwal,Jessica Antosiewicz-Bourget,Isabel Canto,Alessandra Giorgetti,Mason A. Israel,Evangelos Kiskinis,Je-Hyuk Lee,Yuin-Han Loh,Philip D. Manos,Nuria Montserrat,Athanasia D. Panopoulos,Sergio Ruiz,Melissa L. Wilbert,Junying Yu,Ewen F. Kirkness,Juan Carlos Izpisua Belmonte,Derrick J. Rossi,James A. Thomson,Kevin Eggan,George Q. Daley,Lawrence S.B. Goldstein,Kun Zhang +25 more
TL;DR: It is shown that 22 human induced pluripotent stem (hiPS) cell lines reprogrammed using five different methods each contained an average of five protein-coding point mutations in the regions sampled, and that hiPS cells acquire genetic modifications in addition to epigenetic modifications.
Journal ArticleDOI
Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease.
Gorazd B. Stokin,Concepción Lillo,Tomás L. Falzone,Richard G. Brusch,Edward Rockenstein,Stephanie L. Mount,Rema Raman,Peter Davies,Eliezer Masliah,David S. Williams,Lawrence S.B. Goldstein +10 more
TL;DR: Reductions in microtubule-dependent transport may stimulate proteolytic processing of β-amyloid precursor protein, resulting in the development of senile plaques and Alzheimer's disease.
Journal ArticleDOI
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice.
A. M. Clement,Minh Dang Nguyen,E. A. Roberts,E. A. Roberts,M. L. Garcia,M. L. Garcia,Séverine Boillée,Séverine Boillée,M. Rule,Andrew P. McMahon,Wilder Doucette,D. Siwek,Robert J. Ferrante,Robert H. Brown,Jean-Pierre Julien,Lawrence S.B. Goldstein,Lawrence S.B. Goldstein,Don W. Cleveland,Don W. Cleveland +18 more
TL;DR: Nonneuronal cells that do not express mutant SOD1 delay degeneration and significantly extend survival of mutant-expressing motor neurons.
Journal ArticleDOI
Bead movement by single kinesin molecules studied with optical tweezers
TL;DR: The results of this study are consistent with a model in which kinesin detaches briefly from the microtubule during a part of each mechanochemical cycle, rather than a models in whichKinesin remains bound at all times.