L
Lawrence Toll
Researcher at Torrey Pines Institute for Molecular Studies
Publications - 135
Citations - 6462
Lawrence Toll is an academic researcher from Torrey Pines Institute for Molecular Studies. The author has contributed to research in topics: Receptor & Nociceptin receptor. The author has an hindex of 38, co-authored 130 publications receiving 6000 citations. Previous affiliations of Lawrence Toll include Centre national de la recherche scientifique & Washington University in St. Louis.
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Journal ArticleDOI
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.
Jean-Claude Meunier,Catherine Mollereau,Lawrence Toll,Lawrence Toll,Charles Suaudeau,Christiane Moisand,Paul Alvinerie,Jean-Luc Butour,Jean-Claude Guillemot,Pascual Ferrara,Bernard Monsarrat,Honoré Mazarguil,Gilbert Vassart,Marc Parmentier,Jean Costentin +14 more
TL;DR: Data indicate that the newly discovered heptadecapeptide is an endogenous agonist of the ORL1 receptor and that it may be endowed with pro-nociceptive properties.
Journal ArticleDOI
Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems
TL;DR: How NOP pharmacology intersects, contrasts, and interacts with the mu opioid receptor in terms of tertiary structure and mechanism of receptor activation; location of receptors in the central nervous system; mechanisms of desensitization and downregulation; cellular actions; intracellular signal transduction pathways; and behavioral actions with respect to analgesia, tolerance, dependence, and reward is discussed.
Journal Article
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Lawrence Toll,I. Berzetei‐Gurske,Polgar W,Brandt,Adapa Id,Rodriguez L,Schwartz Rw,Haggart D,O'Brien A,White A,Kennedy Jm,Craymer K,Farrington L,Auh Js +13 more
Journal Article
Binding and In Vitro Activities of Peptides with High Affinity for the Nociceptin/Orphanin FQ Receptor, ORL1
Colette T. Dooley,Christine G. Spaeth,Ilona P. Berzetei-Gurske,Karen Craymer,Indira D. Adapa,Susan R. Brandt,Richard A. Houghten,Lawrence Toll +7 more
TL;DR: Binding studies indicated that these five peptides have affinity for ORL1 in the nanomolar range, similar to the recently discovered endogenous ligand called nociceptin and orphanin FQ (N/OFQ), which could enable them to bind to the negatively charged second extracellular loop thought to be a likely binding site for N/OF Q.
Journal ArticleDOI
Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors.
Ruin Moaddel,Galia Abdrakhmanova,Joanna Kozak,Krzysztof Jozwiak,Lawrence Toll,Lucita Jimenez,Avraham Rosenberg,Thao Tran,Yingxian Xiao,Carlos A. Zarate,Irving W. Wainer +10 more
TL;DR: The results suggest that the inhibitory activity of ketamine metabolites at the α7-nicotinic acetylcholine receptor may contribute to the clinical effect of the drug.