Lea Hembach

TL;DR: These pure and fully defined chitosans will allow to investigate the particular influence of DP, DA, and PA on the biological activities of chitOSans, improving the basic understanding of their modes of action and increasing their usefulness in industrial applications.

TL;DR: The detailed functional analysis of CnCda4, a chitin deacetylase with unusual subsite specificity resulting in a preference for chitosan rather than chitIn, is described, showing that the enzyme probably helps the pathogen to evade the host immune system by furtherDeacetylating exposed chitan, making the fungus less susceptible to host immunosurveillance.

TL;DR: Differences in localization, evolution, expression and activities provide explanations underlying the greater potential of centric diatoms for chitin biosynthesis, paving the way for in vitro applications of novel CDAs.

TL;DR: This work explains for the first time, the cell-density-dependent synchronicity of QS responses as the function of a single protein, the LuxR-like activator, capable of coordinating the temporal response of a population of cells in the absence of cell-to-cell communication.

TL;DR: In this paper, the crystal structure of an Aspergillus niger CDA (AngCDA) was determined using molecular dynamics simulations, backed up with a variety of in vitro activity assays using different well-defined polymeric and oligomeric substrates.