L
Leah Eunjung Kim
Researcher at Daegu Gyeongbuk Institute of Science and Technology
Publications - 4
Citations - 191
Leah Eunjung Kim is an academic researcher from Daegu Gyeongbuk Institute of Science and Technology. The author has contributed to research in topics: Autophagy & MAP1LC3B. The author has an hindex of 4, co-authored 4 publications receiving 99 citations. Previous affiliations of Leah Eunjung Kim include Florey Institute of Neuroscience and Mental Health.
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Journal ArticleDOI
TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia.
Ji-Won Lee,Hyeri Nam,Leah Eunjung Kim,Yoonjeong Jeon,Hyunjung Min,Shinwon Ha,Younghwan Lee,Seon Young Kim,Sung Joong Lee,Eun Kyoung Kim,Seong-Woon Yu +10 more
TL;DR: It is shown that autophagic flux and expression of autophagy-related (Atg) genes in microglia are significantly suppressed upon TLR4 activation by lipopolysaccharide (LPS), in contrast to their stimulation by LPS in macrophages.
Journal ArticleDOI
A translocator protein 18 kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation
Ji Won Lee,Leah Eunjung Kim,Hyun-Jung Shim,Eun Kyoung Kim,Won Chan Hwang,Do Sik Min,Seong-Woon Yu +6 more
TL;DR: It is demonstrated for the first time that TSPO ligands, especially Ro5-4864, potently suppressed ATP-induced NLRP3 inflammasome activation in THP-1 and BMDM cells.
Journal ArticleDOI
GSK3B induces autophagy by phosphorylating ULK1
Hye Young Ryu,Leah Eunjung Kim,Hyeonjeong Jeong,Bo Kyoung Yeo,Ji-Won Lee,Hyeri Nam,Shinwon Ha,Hyun-Kyu An,Hyunhee Park,Seonghee Jung,Kyung Min Chung,Jiyea Kim,Byung-Hoon Lee,Heesun Cheong,Eun Kyoung Kim,Seong-Woon Yu +15 more
TL;DR: Following insulin withdrawal, GSK3B directly interacted with and activated ULK1 via phosphorylation of S405 and S415 within the GABARAP-interacting region, revealing the importance of G SK3B-mediated phosphorylated for ULK 1 regulation and autophagy induction and potentially for tumorigenesis.
Journal ArticleDOI
Neurocircuitry of fear extinction in adult and juvenile rats.
Despina E. Ganella,Ly Dao Nguyen,Liubov Lee-Kardashyan,Leah Eunjung Kim,Antonio G. Paolini,Jee Hyun Kim,Jee Hyun Kim +6 more
TL;DR: In contrast to adult rodents, juvenile rodents fail to show relapse following extinction of conditioned fear, and novel insight is provided into the neural process underlying extinction, especially in the juvenile period.