Showing papers by "Lee Edwards published in 2006"
TL;DR: In this paper, the authors adopt a relational view of public relations as a profession defined by its relationships to explain the nature of power in public relations, and use Bourdieu's framework of fields, structures, habitus and capital.
84 citations
TL;DR: The optimization from a high throughput screening hit, of a series of 6-aryl-7-isopropylquinazolinones that are TRPV1 antagonists in vitro are described and it is demonstrated that one compound is active in vivo against capsaicin-induced hyperalgesia and in models of neuropathic and nociceptive pain in the rat.
Abstract: Vanilloid receptor 1 (VR1, TRPV1) is a cation-selective ion channel that is expressed on primary afferent neurons and is upregulated following inflammation and nerve damage. Blockers of this channel may have utility in the treatment of chronic nociceptive and neuropathic pain. Here, we describe the optimization from a high throughput screening hit, of a series of 6-aryl-7-isopropylquinazolinones that are TRPV1 antagonists in vitro. We also demonstrate that one compound is active in vivo against capsaicin-induced hyperalgesia and in models of neuropathic and nociceptive pain in the rat.
54 citations
Patent•
05 Dec 2006TL;DR: In this article, a novel heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, their use as medicaments and to medicaments comprising them, are presented.
Abstract: The invention relates to novel heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them. The compounds (I) are antagonists of VRl receptors.
5 citations