Showing papers by "Lee Edwards published in 2007"

Naphthalen -1 -yl -(4 -pentyloxynaphthalen -1 -yl)methanone : A potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration

Abstract: Selective activation of peripheral cannabinoid CB1 receptors has the potential to become a valuable therapy for chronic pain conditions as long as central nervous system effects are attenuated. A new class of cannabinoid ligands was rationally designed from known aminoalkylindole agonists and showed good binding and functional activities at human CB1 and CB2 receptors. This has led to the discovery of a novel CB1/CB2 dual agonist, naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (13), which displays good oral bioavailability, potent antihyperalgesic activity in animal models, and limited brain penetration.

Pyrazolo [3, 4-d] pyrimidine derivatives useful to treat respiratory disorders

Abstract: The present invention concerns a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, where R1-R3 and Y are defined in the description, and its use in the treatment of disorders in which pi3 kinase is implicated

Dérivés de pyrazolo [3, 4-d] pyrimidine utilisés pour traiter les troubles respiratoires

Abstract: La presente invention concerne un compose de formule (I) ou un sel ou un solvate pharmaceutiquement acceptable de celui-ci, dans laquelle R1-R3 et Y sont definis dans la description, et son utilisation dans le traitement de troubles dans lesquels la kinase pi3 est impliquee.