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Lee Edwards

Bio: Lee Edwards is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Epithelial sodium channel & Cystic fibrosis. The author has an hindex of 25, co-authored 102 publications receiving 1673 citations. Previous affiliations of Lee Edwards include University of Manchester & University of Hertfordshire.


Papers
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Journal ArticleDOI
TL;DR: A broad range of synthetic photochemical transformations were optimized in both reactor modes and their yields and productivities compared and it was revealed that the productivity of flow reactors varied very little to that of their batch counterparts when the key reaction parameters were matched.
Abstract: The use of flow photochemistry and its apparent superiority over batch has been reported by a number of groups in recent years. To rigorously determine whether flow does indeed have an advantage over batch, a broad range of synthetic photochemical transformations were optimized in both reactor modes and their yields and productivities compared. Surprisingly, yields were essentially identical in all comparative cases. Even more revealing was the observation that the productivity of flow reactors varied very little to that of their batch counterparts when the key reaction parameters were matched. Those with a single layer of fluorinated ethylene propylene (FEP) had an average productivity 20% lower than that of batch, whereas three-layer reactors were 20% more productive. Finally, the utility of flow chemistry was demonstrated in the scale-up of the ring-opening reaction of a potentially explosive [1.1.1] propellane with butane-2,3-dione.

146 citations

Journal ArticleDOI
Lee Edwards1
TL;DR: In this article, the importance of paradigmatic variety in the scholarly field of public relations is considered and the role of conflict and cooperation between different paradigms play in the development of academic fields.
Abstract: In this article I consider the importance of paradigmatic variety in the scholarly field of public relations. I reflect on the role that both conflict and cooperation between different paradigms play in the development of academic fields, and review definitions of public relations to examine the extent to which both are present in public relations scholarship. Based on this discussion, I consider the assumptions that underpin existing approaches to public relations in order to reveal the ways in which they are connected, as well as differentiated, along a series of continua. I conclude by proposing a new definition of public relations, as flow rather than organizational function, that can accommodate the range of research encompassed by these continua, thereby facilitating greater unity, inclusivity and, I would hope, dialogue in the field.

129 citations

Journal ArticleDOI
TL;DR: A pharmaceutical industry viewpoint on how the fundamental laws of photochemistry are used to identify the parameters required to implement photochemistry from lab to scale is presented.
Abstract: A pharmaceutical industry viewpoint on how the fundamental laws of photochemistry are used to identify the parameters required to implement photochemistry from lab to scale. Parameters such as photon stoichiometry and light intensity are highlighted within to inform future publications.

97 citations

Journal ArticleDOI
TL;DR: A new class of cannabinoid ligands was rationally designed from known aminoalkylindole agonists and showed good binding and functional activities at human CB1 and CB2 receptors, which led to the discovery of a novel CB1/CB2 dual agonist, naphthalen-1-yl-(4-pentyloxynaphthalanone), which displays good oral bioavailability, potent antihyperalgesic activity in animal models, and limited brain penetration.
Abstract: Selective activation of peripheral cannabinoid CB1 receptors has the potential to become a valuable therapy for chronic pain conditions as long as central nervous system effects are attenuated. A new class of cannabinoid ligands was rationally designed from known aminoalkylindole agonists and showed good binding and functional activities at human CB1 and CB2 receptors. This has led to the discovery of a novel CB1/CB2 dual agonist, naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (13), which displays good oral bioavailability, potent antihyperalgesic activity in animal models, and limited brain penetration.

93 citations

BookDOI
25 Feb 2011
TL;DR: In this article, the authors discuss the implications of a socio-cultural 'turn' in public relations scholarship Lee Edwards, Manchester Business School (University of Manchester) and Caroline E. M. Hodges, Bournemouth University.
Abstract: Contributors Acknowledgements Introduction: Implications of a (radical) socio-cultural 'turn' in public relations scholarship Lee Edwards, Manchester Business School (University of Manchester) and Caroline E. M. Hodges, Bournemouth University Chapter 1. Imagining public relations anthropology Jacquie L'Etang, Stirling Media Institute Chapter 2. Public relations in the postmodern city: An ethnographic account of PR occupational culture in Mexico City Caroline E. M. Hodges, Bournemouth University Chapter 3. Public relations and storytelling Paul Elmer, University of Central Lancashire Chapter 4. Public relations and society: A Bourdieuvian perspective Lee Edwards, Manchester Business School (University of Manchester) Chapter 5. Diversity in public relations Lee Edwards, Manchester Business School (University of Manchester) Chapter 6. Communication for social transformation Caroline E. M. Hodges, Bournemouth University and Nilam McGrath, Leeds University Business School Chapter 7. Pragmatism, semiotics and sacred truth Steve Mackey, Deakin University Chapter 8. Bubble Wrap - Social Media, Public Relations, Culture and Society Kristin Demetrious, Deakin University

91 citations


Cited by
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Journal ArticleDOI
TL;DR: In this paper, Imagined communities: Reflections on the origin and spread of nationalism are discussed. And the history of European ideas: Vol. 21, No. 5, pp. 721-722.

13,842 citations

01 Jan 2015
TL;DR: Familiarity, ease of access, trust, and awareness of risks, will all be important for the future.
Abstract: 萨义德以其独特的双重身份,对西方中心权力话语做了分析,通过对文学作品、演讲演说等文本的解读,将O rie n ta lis m——"东方学",做了三重释义:一门学科、一种思维方式和一种权力话语系统,对东方学权力话语做了系统的批判,同时将东方学放入空间维度对东方学文本做了细致的解读。

3,845 citations

Journal Article
TL;DR: Thaler and Sunstein this paper described a general explanation of and advocacy for libertarian paternalism, a term coined by the authors in earlier publications, as a general approach to how leaders, systems, organizations, and governments can nudge people to do the things the nudgers want and need done for the betterment of the nudgees, or of society.
Abstract: NUDGE: IMPROVING DECISIONS ABOUT HEALTH, WEALTH, AND HAPPINESS by Richard H. Thaler and Cass R. Sunstein Penguin Books, 2009, 312 pp, ISBN 978-0-14-311526-7This book is best described formally as a general explanation of and advocacy for libertarian paternalism, a term coined by the authors in earlier publications. Informally, it is about how leaders, systems, organizations, and governments can nudge people to do the things the nudgers want and need done for the betterment of the nudgees, or of society. It is paternalism in the sense that "it is legitimate for choice architects to try to influence people's behavior in order to make their lives longer, healthier, and better", (p. 5) It is libertarian in that "people should be free to do what they like - and to opt out of undesirable arrangements if they want to do so", (p. 5) The built-in possibility of opting out or making a different choice preserves freedom of choice even though people's behavior has been influenced by the nature of the presentation of the information or by the structure of the decisionmaking system. I had never heard of libertarian paternalism before reading this book, and I now find it fascinating.Written for a general audience, this book contains mostly social and behavioral science theory and models, but there is considerable discussion of structure and process that has roots in mathematical and quantitative modeling. One of the main applications of this social system is economic choice in investing, selecting and purchasing products and services, systems of taxes, banking (mortgages, borrowing, savings), and retirement systems. Other quantitative social choice systems discussed include environmental effects, health care plans, gambling, and organ donations. Softer issues that are also subject to a nudge-based approach are marriage, education, eating, drinking, smoking, influence, spread of information, and politics. There is something in this book for everyone.The basis for this libertarian paternalism concept is in the social theory called "science of choice", the study of the design and implementation of influence systems on various kinds of people. The terms Econs and Humans, are used to refer to people with either considerable or little rational decision-making talent, respectively. The various libertarian paternalism concepts and systems presented are tested and compared in light of these two types of people. Two foundational issues that this book has in common with another book, Network of Echoes: Imitation, Innovation and Invisible Leaders, that was also reviewed for this issue of the Journal are that 1 ) there are two modes of thinking (or components of the brain) - an automatic (intuitive) process and a reflective (rational) process and 2) the need for conformity and the desire for imitation are powerful forces in human behavior. …

3,435 citations