Lee M. Ellis

TL;DR: C. Glenn Begley and Lee M. Ellis propose how methods, publications and incentives must change if patients are to benefit.

TL;DR: It is demonstrated that exposure of HCT116 human colon carcinoma cells to IGF-1 induces the expression of HIF-1α, the regulated subunit of hypoxia-inducible factor 1, a known transactivator of the VEGF gene.

TL;DR: Efficacy and tolerability of FOLFIRI + B appeared favorable to historical controls in this single arm study, and there was a shift in balance of CAFs, with a rise in alternate pro-angiogenic cytokines and myeloid recruitment factors in subsets of patients that may represent mechanisms of resistance.

TL;DR: It is shown that, without direct cell-cell contact, ECs secrete factors that promoted the CSC phenotype in CRC cells via Notch activation, and ECs play an active role in promoting Notch signaling and the C SC phenotype by secreting soluble Jagged-1.

TL;DR: The current study evaluated the effect of bevacizumab added to fluoropyrimidine‐plus‐oxaliplatin (5FU/OX) chemotherapy for colorectal liver metastases (CLM) on the pathologic response and nontumorous liver histology.