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Lei Wang

Bio: Lei Wang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Precipitation & Medicine. The author has an hindex of 50, co-authored 429 publications receiving 9543 citations. Previous affiliations of Lei Wang include Taizhou University & Peking University.


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TL;DR: This paper presents a meta-analyses of the immune system’s response to strokes and shows clear patterns of decline in the number of strokes and in the patterns of strokes that occur after certain types of injuries.
Abstract: The original version of this article contained an error in the name of one of the co-authors (Glyn Nigel Stacey). This has been corrected in the PDF and HTML versions of the article.

2 citations

Journal ArticleDOI
TL;DR: In this article, the authors investigated the relationship between the concentration of neuropeptide Y (NPY) in synovial fluid of knee, pain of knee osteoarthritis, and structural severity of KOA.
Abstract: The precise etiology of knee osteoarthritis (KOA) pain remains highly controversial and there is no known effective treatment. Due to the known and suggested effects of neuropeptide Y (NPY) on pain, we have sought to investigate the relationship between the concentration of NPY in synovial fluid of knee, pain of KOA, and structural severity of KOA. One hundred KOA patients and twenty healthy participants (control group) were recruited. The pain and the radiographic grade of KOA were assessed separately by Hideo Watanabe’s pain score and Tomihisa Koshino’s scoring system. Synovial fluid of knee from all participants was collected with arthrocentesis. Radioimmunoassay was used to examine the concentration of NPY in synovial fluid of knee. Concentrations of NPY in synovial fluid were significantly higher in KOA patients (124.7 ± 33.4 pg/mL) compared with controls (64.8 ± 26.3 pg/mL) (p = 0.0297). According to Hideo Watanabe’s pain score, 100 KOA patients were divided into 5 subgroups: no pain (n = 12), mild pain (n = 25), moderate pain (n = 37), strong pain (n = 19) and severe pain (n = 7). Within the KOA group, significantly higher concentrations of NPY were found in each subgroup as pain intensified (no pain 81.4 ± 11.7 pg/mL, mild pain 99.1 ± 23.2 pg/mL, moderate pain 119.9 ± 31.5 pg/mL, strong pain 171.2 ± 37.3 pg/mL and severe pain 197.3 ± 41.9 pg/mL). Meanwhile, according to Tomihisa Koshino’s scoring system, 100 KOA patients were divided into 3 subgroups: early stage (n = 30), middle stage (n = 53), advanced stage (n = 17). Concentrations of NPY in middle and advanced stage groups of KOA patients were significant higher than early stage group of KOA patients (early stage 96.4 ± 27.1 pg/mL, middle stage 153.3 ± 16.9 pg/mL, advanced stage 149.5 ± 36.7 pg/mL) (p = 0.0163, p = 0.0352). Concentrations of NPY in advanced stage group of KOA patients has no significant difference compare with middle stage group of KOA patients (p = 0. 2175). This study demonstrated the presence and variation of concentrations of NPY in the KOA joint fluid, suggesting a role for NPY as a putative regulator of pain transmission and perception in KOA pain.

2 citations

Journal Article
Chi Lq, Lu X, Lei Wang, Shiqing Liu1, Ning Ding1, H Y Zhang1 
TL;DR: The parturient women carrying CT heterozygotes and TT homozygotes of CYP3A4 rs2242480 required less sufentanil in accouchement sans douleur, consistent with the expected analgesic standards.
Abstract: Objective: To investigate the relationship between single nucleotide polymorphisms( SNPs)of cytochrome P450( CYP450) 3A4 rs2242480 and inter-individual differences of sufentanil consumption in accouchement sans douleur. Methods: A total of 131 parturient women were collected. According to the distribution of genotypes and allele frequencies of rs2242480,the doses of sufentanil were individually designed. CC homozygotes were given the standard analgesia dose,CT heterozygotes and TT homozygotes were given 87. 6% of standard sufentanil dose. Results: Visual analogue score( VAS) between CC group and CT / TT group were 3. 67 ± 1. 2 and 3. 44 ± 1. 5,consistent with the expected analgesic standards.The difference was not statistically significant. Conclusion: The parturient women carrying CT heterozygotes and TT homozygotes of CYP3A4 rs2242480 required less sufentanil in accouchement sans douleur.

2 citations

Journal ArticleDOI
TL;DR: In this article , the authors investigated the relationship between pilots' total flight hours (TFH), levels of hazardous attitude (HA), and flight safety performance using a sample of 45 Chinese commercial airline pilots.

2 citations

Journal ArticleDOI
TL;DR: In this article, a polymethyl methacrylate-based bionic fabricated curved bar with millimetre cone arrays is fabricated by 3D printing technology, which shows good performance in anti-bending, anti-twisting and anti-stretching.

2 citations


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5,680 citations

Journal Article
TL;DR: In this article, the authors present a document, redatto, voted and pubblicato by the Ipcc -Comitato intergovernativo sui cambiamenti climatici - illustra la sintesi delle ricerche svolte su questo tema rilevante.
Abstract: Cause, conseguenze e strategie di mitigazione Proponiamo il primo di una serie di articoli in cui affronteremo l’attuale problema dei mutamenti climatici. Presentiamo il documento redatto, votato e pubblicato dall’Ipcc - Comitato intergovernativo sui cambiamenti climatici - che illustra la sintesi delle ricerche svolte su questo tema rilevante.

4,187 citations

01 Jan 1989
TL;DR: In this article, a two-dimensional version of the Pennsylvania State University mesoscale model has been applied to Winter Monsoon Experiment data in order to simulate the diurnally occurring convection observed over the South China Sea.
Abstract: Abstract A two-dimensional version of the Pennsylvania State University mesoscale model has been applied to Winter Monsoon Experiment data in order to simulate the diurnally occurring convection observed over the South China Sea. The domain includes a representation of part of Borneo as well as the sea so that the model can simulate the initiation of convection. Also included in the model are parameterizations of mesoscale ice phase and moisture processes and longwave and shortwave radiation with a diurnal cycle. This allows use of the model to test the relative importance of various heating mechanisms to the stratiform cloud deck, which typically occupies several hundred kilometers of the domain. Frank and Cohen's cumulus parameterization scheme is employed to represent vital unresolved vertical transports in the convective area. The major conclusions are: Ice phase processes are important in determining the level of maximum large-scale heating and vertical motion because there is a strong anvil componen...

3,813 citations

Journal ArticleDOI
TL;DR: The progress in the research and development of CQDs is reviewed with an emphasis on their synthesis, functionalization and technical applications along with some discussion on challenges and perspectives in this exciting and promising field.
Abstract: Fluorescent carbon nanoparticles or carbon quantum dots (CQDs) are a new class of carbon nanomaterials that have emerged recently and have garnered much interest as potential competitors to conventional semiconductor quantum dots. In addition to their comparable optical properties, CQDs have the desired advantages of low toxicity, environmental friendliness low cost and simple synthetic routes. Moreover, surface passivation and functionalization of CQDs allow for the control of their physicochemical properties. Since their discovery, CQDs have found many applications in the fields of chemical sensing, biosensing, bioimaging, nanomedicine, photocatalysis and electrocatalysis. This article reviews the progress in the research and development of CQDs with an emphasis on their synthesis, functionalization and technical applications along with some discussion on challenges and perspectives in this exciting and promising field.

3,514 citations