Showing papers by "Leigh T. Canham published in 2006"
TL;DR: This method exploits a combination of capillary forces and selective interfacial coupling chemistry to produce isolable macroscale structures possessing a diverse range of geometries through simple mixing rather than intricate molding processes.
Abstract: We describe in this account a general, yet facile strategy for the directed assembly of bioactive composite materials comprised of an erodible organic polymer such as polycaprolactone and physiologically-resorbable inorganic mesoporous silicon. This method exploits a combination of capillary forces and selective interfacial coupling chemistry to produce isolable macroscale (mm sized) structures possessing a diverse range of geometries through simple mixing rather than intricate molding processes. Furthermore, we demonstrate the ability of such constructs to dissociate into their individual building blocks, with the concomitant release of embedded model compounds in a sustained manner.
32 citations
TL;DR: The controlled release of substances from a semiconducting calcium phosphate/porous Si structure is reported and the effect of bias on the diffusion of the cationic dyes ethidium bromide and acridine orange has been investigated.
Abstract: The controlled release of substances from a semiconducting calcium phosphate/porous Si structure is reported. This is demonstrated principally for the case of the reversible adsorption and release of dyes (such as an anionic salt of fluorescein) upon the switching of the direction of bias to the underlying porous Si/Si substrate. The effect of bias on the diffusion of the cationic dyes ethidium bromide and acridine orange has also been investigated. For these species, their delivery can be mediated in part by the use of a surface layer of the biodegradable polymer poly-caprolactone (PCL).
17 citations
Patent•
03 Mar 2006
TL;DR: In this paper, the use of a silicon-containing material to reduce the amount of hormone required in a method of hormone treatment to achieve a desired response, particularly in hormone replacement therapy (HRT) and especially in the maintenance of post-menopausal bone health and the management or treatment of osteoporosis, was discussed.
Abstract: The invention relates to the use of a silicon-containing material to reduce the amount of hormone required in a method of hormone treatment to achieve a desired response, particularly in hormone replacement therapy (HRT) and especially in the maintenance of post-menopausal bone health and the management or treatment of osteoporosis, and to pharmaceutical compositions for use in such a method.
1 citations