Author
Leigh T. Canham
Other affiliations: Defence Research Agency, Defence Science and Technology Laboratory, University of St Andrews
Bio: Leigh T. Canham is an academic researcher from University of Birmingham. The author has contributed to research in topics: Porous silicon & Silicon. The author has an hindex of 42, co-authored 160 publications receiving 18268 citations. Previous affiliations of Leigh T. Canham include Defence Research Agency & Defence Science and Technology Laboratory.
Papers published on a yearly basis
Papers
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Patent•
01 Nov 2011
TL;DR: The presente invention porte sur des dispositifs pouvant etre biologiquement erodes, tels que des implants, pour l'administration d'une maniere controlee d'agents therapeutiques, en particulier des molecules de grande dimension, telles que des proteines and des anticorps as mentioned in this paper.
Abstract: La presente invention porte sur des dispositifs pouvant etre biologiquement erodes, tels que des implants, pour l'administration d'une maniere controlee d'agents therapeutiques, en particulier des molecules de grande dimension, telles que des proteines et des anticorps. Les dispositifs comportent un materiau support a base de silicium poreux impregne de l'agent therapeutique. Le dispositif peut etre utilise in vitro ou in vivo pour administrer l'agent therapeutique, de preference d'une maniere controlee au cours d'un laps de temps prevu, telle qu'au cours de plusieurs jours, de plusieurs semaines ou de plusieurs mois. Le dispositif peut etre utilise pour traiter ou prevenir des etats d'un patient, tels que des maladies chroniques.
Patent•
20 Feb 2002
TL;DR: In this article, a produit therapeutique interne renfermant (i) un composant anti-cancereux selectionne parmi un radionucleotide et/ou un medicament cytotoxique, and (ii) un Composant de silicium selectionn parmi du siliciam resorbable, du sililicium biocompatible, dusilicium bioactif, du SILICium poreux, du Silicium polycristallin, du ISC amorphe et du SIL
Abstract: L'invention concerne le traitement du cancer et plus specialement un produit therapeutique interne renfermant (i) un composant anti-cancereux selectionne parmi un radionucleotide et/ou un medicament cytotoxique, et (ii) un composant de silicium selectionne parmi du silicium resorbable, du silicium biocompatible, du silicium bioactif, du silicium poreux, du silicium polycristallin, du silicium amorphe et du silicium en masse cristallin, le produit therapeutique interne etant destine au traitement du cancer.
TL;DR: In this paper , a simple green method of magnesiothermic co-reduction for the synthesis of mesoporous, magnetic and biodegradable iron silicide nanoparticles (FeSi NPs) as applied to photothermal therapy (PTT) was developed.
Abstract: Photothermal nanomaterials have shown great potential for photothermal therapy. In this study, we developed a simple green method of magnesiothermic co-reduction for the synthesis of mesoporous, magnetic and biodegradable iron silicide nanoparticles (FeSi NPs) as applied to photothermal therapy (PTT). Starting from biogenic tabasheer extracted from bamboo and Fe2O3, the resultant FeSi NPs with a much lower band gap exhibited excellent optical absorption with a photothermal conversion efficiency of 76.2%, indicating a good photothermal performance. The weight extinction coefficient was measured to be 13.3 L g-1 cm-1 at 1064 nm (second near-infrared window, NIR-II), which surpassed the performance of other competitive Si-based and Fe-based photothermal agents. Results of the cell viability assay showed that cells could be killed by NIR-II laser irradiation with the synthesized FeSi NPs. In vivo results on mice showed clearly an efficient suppression of tumour growth by photothermal treatment with FeSi NPs. FeSi NPs were found to be biodegradable in simulated body fluids. The results from our work indicate that FeSi NPs are a new class of promising photothermal agents (PTAs) for application in cancer therapy.
Patent•
12 Jan 2018
TL;DR: In this article, the authors described a biodegradable implant for the controlled delivery of therapeutic agents, in particular large molecules such as proteins and antibodies, which contain a porous silicon carrier material impregnated with a therapeutic agent.
Abstract: FIELD: medicine.SUBSTANCE: biodegradable devices are described, such as implants for the controlled delivery of therapeutic agents, in particular large molecules such as proteins and antibodies. The devices contain a porous silicon carrier material impregnated with a therapeutic agent. An improved dosage form for controlled release of therapeutic agents can be used in vitro or in vivo to deliver the therapeutic agent during an estimated period of time, for example, several days, weeks or months.EFFECT: device can be used to treat or prevent the patient's conditions, such as chronic diseases.19 cl, 3 dwg, 6 tbl, 6 ex
TL;DR: In this article , it is shown that the rate of non-radiative recombination depends on the composition of surface passivation and the degree of the charge carriers' quantum confinement.
Abstract: A range of the distinctive physical properties, comprising high surface-to-volume ratio, possibility to achieve mechanical and chemical stability after a tailored treatment, controlled quantum confinement and the room-temperature photoluminescence, combined with mass production capabilities offer porous silicon unmatched capabilities required for the development of electro-optical devices. Yet, the mechanism of the charge carrier dynamics remains poorly controlled and understood. In particular, non-radiative recombination, often the main process of the excited carrier's decay, has not been adequately comprehended to this day. Here we show, that the recombination mechanism critically depends on the composition of surface passivation. That is, hydrogen passivated material exhibits Shockley-Read-Hall type of decay, while for oxidised surfaces, it proceeds by two orders of magnitude faster and exclusively through the Auger process. Moreover, it is possible to control the source of recombination in the same sample by applying a cyclic sequence of hydrogenation-oxidation-hydrogenation processes, and, consequently switching on-demand between Shockley-Read-Hall and Auger recombinations. Remarkably, irregardless of the recombination mechanism, the rate constant scales inversely with the average volume of individual silicon nanocrystals contained in the material. Thus, the type of the non-radiative recombination is established by the composition of the passivation, while its rate depends on the degree of the charge carriers' quantum confinement.
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TL;DR: In this article, the authors focus on the properties of quantum dots and their ability to join the dots into complex assemblies creates many opportunities for scientific discovery, such as the ability of joining the dots to complex assemblies.
Abstract: Current research into semiconductor clusters is focused on the properties of quantum dots-fragments of semiconductor consisting of hundreds to many thousands of atoms-with the bulk bonding geometry and with surface states eliminated by enclosure in a material that has a larger band gap. Quantum dots exhibit strongly size-dependent optical and electrical properties. The ability to join the dots into complex assemblies creates many opportunities for scientific discovery.
10,737 citations
TL;DR: Dye-sensitized solar cells (DSCs) offer the possibilities to design solar cells with a large flexibility in shape, color, and transparency as mentioned in this paper, and many DSC research groups have been established around the world.
Abstract: Dye-sensitized solar cells (DSCs) offer the possibilities to design solar cells with a large flexibility in shape, color, and transparency. DSC research groups have been established around the worl ...
8,707 citations
TL;DR: This observation shows that quantum confinement in layered d-electron materials like MoS(2), a prototypical metal dichalcogenide, provides new opportunities for engineering the electronic structure of matter at the nanoscale.
Abstract: Novel physical phenomena can emerge in low-dimensional nanomaterials. Bulk MoS2, a prototypical metal dichalcogenide, is an indirect bandgap semiconductor with negligible photoluminescence. When the MoS2 crystal is thinned to monolayer, however, a strong photoluminescence emerges, indicating an indirect to direct bandgap transition in this d-electron system. This observation shows that quantum confinement in layered d-electron materials like MoS2 provides new opportunities for engineering the electronic structure of matter at the nanoscale.
7,886 citations
TL;DR: In this article, the authors present methods of severe plastic deformation and formation of nanostructures, including Torsion straining under high pressure, ECA pressing, and multiple forging.
5,763 citations
TL;DR: Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry that can provide essential breakthroughs in the fight against cancer.
Abstract: Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry. These devices include nanovectors for the targeted delivery of anticancer drugs and imaging contrast agents. Nanowires and nanocantilever arrays are among the leading approaches under development for the early detection of precancerous and malignant lesions from biological fluids. These and other nanodevices can provide essential breakthroughs in the fight against cancer.
4,241 citations