L
Leila Nahidiazar
Researcher at Netherlands Cancer Institute
Publications - 16
Citations - 1002
Leila Nahidiazar is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Integrin & Transmembrane domain. The author has an hindex of 11, co-authored 16 publications receiving 773 citations.
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Journal ArticleDOI
Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells
Jop Kind,Jop Kind,Ludo Pagie,Sandra S. de Vries,Leila Nahidiazar,Siddharth S. Dey,Magda Bienko,Ye Zhan,Bryan R. Lajoie,Carolyn A. de Graaf,Mario Amendola,Geoffrey Fudenberg,Maxim Imakaev,Leonid A. Mirny,Kees Jalink,Job Dekker,Alexander van Oudenaarden,Bas van Steensel +17 more
TL;DR: The consistency of NL contacts is inversely linked to gene activity in single cells and correlates positively with the heterochromatic histone modification H3K9me3, which highlights fundamental principles of single-cell chromatin organization.
Journal ArticleDOI
Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway
Ruud H. Wijdeven,Hans Janssen,Leila Nahidiazar,Lennert Janssen,Lennert Janssen,Kees Jalink,Ilana Berlin,Ilana Berlin,Jacques Neefjes,Jacques Neefjes +9 more
TL;DR: ORP1L, via its liganding by lipids and the formation of contacts between autophagic vacuoles and the ER, governs the last steps in autophagy that lead to the lysosomal degradation of cytosolic material.
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Optimizing Imaging Conditions for Demanding Multi-Color Super Resolution Localization Microscopy
Leila Nahidiazar,Alexandra V. Agronskaia,Jorrit Broertjes,Bram van den Broek,Kees Jalink,Kees Jalink +5 more
TL;DR: A new imaging buffer is described, OxEA, that supports 3-color imaging of the popular Alexa dyes and is shown to collect very large series of images from the same cell, enabling image stitching, extended 3D imaging as well as multi-color recording.
Journal ArticleDOI
Hemidesmosomes modulate force generation via focal adhesions.
Wei Wang,Alba Zuidema,Lisa te Molder,Leila Nahidiazar,Liesbeth Hoekman,Thomas Schmidt,Stefano Coppola,Arnoud Sonnenberg +7 more
TL;DR: Through their ability to influence cellular tension, hemidesmosomes also control the localization of αvβ5 in flat clathrin lattices.
Journal ArticleDOI
Modular actin nano-architecture enables podosome protrusion and mechanosensing
Koen van den Dries,Leila Nahidiazar,Johan A. Slotman,Marjolein B. M. Meddens,Elvis Pandzic,Ben Joosten,Marleen Ansems,Joost Schouwstra,Anke Meijer,Raymond Steen,Mietske Wijers,Jack A.M. Fransen,Adriaan B. Houtsmuller,Paul W. Wiseman,Kees Jalink,Alessandra Cambi +15 more
TL;DR: It is reported that podosomes have a modular actin nano-architecture whose organization differs on stiff or soft substrates, and a paradigm for how actin modularity drives invadosome mechanosensing in cells that breach tissue boundaries is revealed.