Author
Leila Youseftabar-Miri
Other affiliations: University of Gilan
Bio: Leila Youseftabar-Miri is an academic researcher from Islamic Azad University. The author has contributed to research in topics: Isatin & Oxindole. The author has an hindex of 8, co-authored 18 publications receiving 244 citations. Previous affiliations of Leila Youseftabar-Miri include University of Gilan.
Topics: Isatin, Oxindole, Ionic liquid, Pyran, Natural bond orbital
Papers
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TL;DR: In this paper, a simple and efficient one-pot approach for assembling some fused spiro[4H-pyran-oxindole] heterocycles by means of three-component reactions between isatins, malononitrile or ethyl cyano-acetate, and 1,3-dicarbonyl compounds is reported.
94 citations
TL;DR: This review focuses on the important progress of 3,4-heterocycle-fused coumarins providing better insight for medicinal chemists on the design and preparation of biologically active heterocycle/coumarins with a significant therapeutic effect in the future.
48 citations
TL;DR: In this paper, an efficient one-pot synthesis of the biologically important spiro[dihydropyridine-oxindole] scaffold was accomplished simply by the reaction of isatin, 2H-indene-1,3-dione and naphthalen-2-amine in aqueous medium.
Abstract: An efficient one-pot synthesis of the biologically important spiro[dihydropyridine-oxindole] scaffold was accomplished simply by the reaction of isatin, 2H-indene-1,3-dione and naphthalen-2-amine in aqueous medium. The scope of this reaction was successfully extended by employing two other reactive ketones (acenaphthylene-1,2-dione and ninhydrin) in place of isatin to access the synthesis of corresponding spirocyclic derivatives.
33 citations
TL;DR: In this paper, a convergent mechanism was suggested for the reactions to account for the selective formation of the spiro-compounds corresponding to the employed components, and this mechanism also works well when acenaphthylene-1,2-dione or 1,2,3-trione is employed in place of isatin and likewise when 2-aminouracil is used instead of naphthalenamine to furnish the structurally related spirocyclic products.
33 citations
TL;DR: A review of recent progress in the direct azidation of C(sp2)-H bonds is presented in this paper, where the review is divided into three major sections: (i) direct olefinic C-H bond azidation; (ii) direct aldehydic H-Bond azidation.
Abstract: Direct functionalization of C–H bonds has attracted great attention in recent years from the perspectives of atom and step economy. In this context, a variety of processes have been developed for the construction of synthetically and biologically important organic azides through the oxidative C–H bonds azidation. In this review, we have summarized recent progress in the direct azidation of C(sp2)–H bonds. The review is divided into three major sections: (i) direct azidation of aromatic C–H bonds; (ii) direct azidation of olefinic C–H bonds; and (iii) direct azidation of aldehydic C–H bonds. Mechanistic aspects of the reactions are considered and discussed in detail.
30 citations
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1,273 citations
TL;DR: In this paper, a review summarizes recent results of multicomponent reactions obtained in unconventional media including water, ionic liquids, polyethylene glycol and bio-based solvents.
498 citations
TL;DR: This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work.
Abstract: Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work. The spirooxindoles in this review are separated into three structural classes, and then further categorized into the method type from which the spirocycle is generated.
254 citations
TL;DR: In this article, a wide variety of 2-amino-4H-chromene derivatives with diverse substituents on the 4Hchromene ring were efficiently prepared via one-pot, three-component reaction of an aromatic aldehyde, malononitrile (or ethyl cyanoacetate), and diverse enolizable C-H activated acidic compounds in the presence of low loading of potassium phthalimide-N-oxyl (POPINO), as a new organocatalyst, in aqueous media.
238 citations
TL;DR: All contributions till March 2015 are surveyed with particular emphasis on metal-free domino reactions for quinoline ring construction and are discussed herein along with mechanistic aspects.
Abstract: Quinoline is one of the most widely investigated scaffolds by synthetic chemists because of its medicinal importance. A wide range of metal-catalyzed, metal-free, multi-step or domino one-pot protocols are reported in the literature for construction of this scaffold. Several reviews have appeared on synthetic aspects of this scaffold, however there is no focused review on metal-free domino one-pot protocols. Domino one-pot protocols offer an opportunity to access highly functionalized final products from simple starting materials. Because of this unique feature of domino protocols, in recent years their utility for generation of molecular libraries has been widely appreciated. In this review, all contributions till March 2015 are surveyed with particular emphasis on metal-free domino reactions for quinoline ring construction and are discussed herein along with mechanistic aspects.
127 citations