L
Leland H. Hartwell
Researcher at Arizona State University
Publications - 125
Citations - 35854
Leland H. Hartwell is an academic researcher from Arizona State University. The author has contributed to research in topics: Saccharomyces cerevisiae & Cell cycle. The author has an hindex of 82, co-authored 125 publications receiving 34951 citations. Previous affiliations of Leland H. Hartwell include Massachusetts Institute of Technology & Fred Hutchinson Cancer Research Center.
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From molecular to modular cell biology.
TL;DR: General principles that govern the structure and behaviour of modules may be discovered with help from synthetic sciences such as engineering and computer science, from stronger interactions between experiment and theory in cell biology, and from an appreciation of evolutionary constraints.
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Checkpoints: controls that ensure the order of cell cycle events
Leland H. Hartwell,Ted Weinert +1 more
TL;DR: It appears that some checkpoints are eliminated during the early embryonic development of some organisms; this fact may pose special problems for the fidelity of embryonic cell division.
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Cell cycle control and cancer
TL;DR: New insights in understanding of the cell cycle reveal how fidelity is normally achieved by the coordinated activity of cyclin-dependent kinases, checkpoint controls, and repair pathways and how this fidelity can be abrogated by specific genetic changes.
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Genetic Control of the Cell Division Cycle in Yeast
TL;DR: Two features which distinguish the cell cycle of Saccharomyces cerevisiae from most other eukaryotes are particularly useful for an analysis of the gene functions that control the cell division cycle.
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The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae
Ted Weinert,Leland H. Hartwell +1 more
TL;DR: Examinations of the genetic basis for this response in the yeast Saccharomyces cerevisiae indicate that the RAD9 gene product is essential for arrest of cell division induced by DNA damage.