Author
Lena Rothmund
Bio: Lena Rothmund is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Curing (chemistry) & UDMA. The author has an hindex of 8, co-authored 8 publications receiving 166 citations.
Topics: Curing (chemistry), UDMA, Deuterated methanol, Saliva, Viability assay
Papers
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TL;DR: Examination of time-related elution indicates that various elution products (e.g. Bis-EMA, BPA) were only released in small quantities during the first 90 days, but in high quantities between day 90 and day 180, and within 180 days no compounds were formed as the products of breakdown.
37 citations
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TL;DR: Ni in the alloy NiTi induced an increase in the toxic potential compared to Ti-MPs, and Ti-NPs induced higher cellular uptake efficiency and higher toxic potential in PDL-hTERT cells.
28 citations
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TL;DR: Salivary and plasma proteins may bind (co)monomers and additives and may contribute to a lower bioavailability of leachables from RBCs in vivo than previously thought.
26 citations
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TL;DR: Leached components from dental resin restorations can induce DNA DSBs and cell death effects in HGFs.
24 citations
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TL;DR: An increment layering technique in a thickness of 2mm or less can lead to an increased elution of some bulk fill components, compared to the elution at a layer thickness of 4mm or more.
24 citations
Cited by
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01 Jan 2013
TL;DR: This meta-analytical study reviewed the literature on the short- and long-term release of components from resin-based dental materials, and to determine how much of those components may leach out in the oral cavity.
Abstract: OBJECTIVES
Resin-based dental materials are not inert in the oral environment, and may release components, initially due to incomplete polymerization, and later due to degradation. Since there are concerns regarding potential toxicity, more precise knowledge of the actual quantity of released eluates is necessary. However, due to a great variety in analytical methodology employed in different studies and in the presentation of the results, it is still unclear to which quantities of components a patient may be exposed. The objective of this meta-analytical study was to review the literature on the short- and long-term release of components from resin-based dental materials, and to determine how much (order of magnitude) of those components may leach out in the oral cavity.
METHODS
Out of an initial set of 71 studies, 22 were included. In spite of the large statistical incertitude due to the great variety in methodology and lack of complete information (detection limits were seldom mentioned), a meta-analytical mean for the evaluated eluates was calculated. To relate the amount of potentially released material components with the size of restorations, the mean size of standard composite restorations was estimated using a 3D graphical program.
RESULTS
While the release of monomers was analyzed in many studies, that of additives, such as initiators, inhibitors and stabilizers, was seldom investigated. Significantly more components were found to be released in organic than in water-based media. Resin-based dental materials might account for the total burden of orally ingested bisphenol A, but they may release even higher amounts of monomers, such as HEMA, TEGDMA, BisGMA and UDMA. Compared to these monomers, similar or even higher amounts of additives may elute, even though composites generally only contain very small amounts of additives. A positive correlation was found between the total quantity of released eluates and the volume of extraction solution.
SIGNIFICANCE
There is a clear need for more accurate and standardized analytical research to determine the long-term release from resin-based materials. Several guidelines for standardization are proposed.
317 citations
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TL;DR: Filler characteristics of a selection of dental resin-based composites were described, aiming at identifying correlations with physico-mechanical properties and testing the relevance of the current classification.
157 citations
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TL;DR: Modulation of the Nrf2-mediated cellular defense response is an effective means for manipulating the sensitivity of cells to dental resin monomers and expands the detailed understanding of the underlying mechanisms of HEMA-induced oxidative stress, and highlighted the cross-talk and interdependence between various NRF2-regulated antioxidant pathways as a major adaptive cell response.
81 citations
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TL;DR: A wise use of the new tools, especially the clinical risk assessment, should aim at preventing the patients, professionals and the environment from harm but should not block the development of novel materials.
77 citations