L
Lennart Eriksson
Researcher at Karolinska University Hospital
Publications - 184
Citations - 16710
Lennart Eriksson is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Partial least squares regression & Quantitative structure–activity relationship. The author has an hindex of 46, co-authored 184 publications receiving 15174 citations. Previous affiliations of Lennart Eriksson include Umeå University & Stockholm University.
Papers
More filters
Journal ArticleDOI
PLS-regression: a basic tool of chemometrics
TL;DR: PLS-regression (PLSR) as mentioned in this paper is the PLS approach in its simplest, and in chemistry and technology, most used form (two-block predictive PLS) is a method for relating two data matrices, X and Y, by a linear multivariate model.
Journal ArticleDOI
Methods for reliability and uncertainty assessment and for applicability evaluations of classification- and regression-based QSARs.
Lennart Eriksson,Joanna Jaworska,Andrew Worth,Mark T. D. Cronin,Robert M McDowell,Paola Gramatica +5 more
TL;DR: This article provides an overview of methods for reliability assessment of quantitative structure-activity relationship (QSAR) models in the context of regulatory acceptance of human health and environmental QSARs.
Journal ArticleDOI
CV‐ANOVA for significance testing of PLS and OPLS® models
TL;DR: In this paper, significance testing for PLS and OPLS (orthogonal PLS) models is described and applied to single-Y cases and is based on ANOVA of the cross-validated residuals (CV-ANOVA).
Journal ArticleDOI
New Chemical Descriptors Relevant for the Design of Biologically Active Peptides. A Multivariate Characterization of 87 Amino Acids
TL;DR: The new extended and updated principal property scales, the z-scales, were calculated and aligned to previously reported z(old)-scales and validated by the use in quantitative sequence-activity modeling (QSAM) of 89 elastase substrate analogues and in a QSAM of 29 neurotensin analogues.