L
Leo A. Paquette
Researcher at Ohio State University
Publications - 484
Citations - 6138
Leo A. Paquette is an academic researcher from Ohio State University. The author has contributed to research in topics: Ring (chemistry) & Total synthesis. The author has an hindex of 36, co-authored 484 publications receiving 6021 citations. Previous affiliations of Leo A. Paquette include Heidelberg University.
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Journal ArticleDOI
Concise Synthesis of cis- and trans-Theaspirones via Oxonium Ion-Initiated Pinacol Ring Expansion
TL;DR: The odoriferous principle of black tea has been produced from 2,2-dimethylcyclopentanone as discussed by the authors, where the reaction sequence begins with 1, 2-addition of 5-lithio-2-methyl-2,3-dihydrofuran to this ketone and immediate acid-catalyzed ring expansion of the resulting carbinols to a separable pair of spiro ethers.
Journal ArticleDOI
Full control of regioselectivity in linear and angular polyquinane construction from squarate esters by incorporation of a leaving group into a single vinyl anion reactant
Leo A. Paquette,Julien Doyon +1 more
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An Enantioselective Approach to the Taxanes: Direct access to functionalized cis‐tricyclo[9.3.1.03,8]pentadecanes via α‐hydroxy ketone and Wagner‐Meerwein rearrangements
TL;DR: The feasibility of the titled reactions for the rapid, enantioselective synthesis of cis-tricyclo precursors to taxusin and taxol has been examined in this article.
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Highly enantioselective total synthesis of natural epoxydictymene. An alkoxy-directed cyclization route to highly strained trans-oxabicyclo[3.3.0]octanes
TL;DR: An enantioselective synthesis of (+)-epoxydictymene, which involves efficient construction of the strained oxabicyclo[3.3.0] octane subunit by irradiation with iodosobenzene diacetate and iodine in cyclohexane solution, is reported in this article.
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Enantioselective total synthesis of (-)-subergorgic acid
TL;DR: In this paper, a completely stereocontrolled total synthesis of (-)-subergorgic acid (1) has been accomplished, where the starting β-hydroxy ketone was prepared in optically pure condition by lipase-promoted hydrolysis of the racemic chloroacetate.