L
Leo A. Paquette
Researcher at Ohio State University
Publications - 484
Citations - 6138
Leo A. Paquette is an academic researcher from Ohio State University. The author has contributed to research in topics: Ring (chemistry) & Total synthesis. The author has an hindex of 36, co-authored 484 publications receiving 6021 citations. Previous affiliations of Leo A. Paquette include Heidelberg University.
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1-Oxaspiro[4.4]nonan-6-ones. Synthetic Access via Oxonium Ion Technology, Optical Resolution, and Conversion into Enantiopure Spirocyclic α,β-Butenolides
Leo A. Paquette,Dafydd R. Owen,Richard Todd Bibart,Christopher K. Seekamp,Alexandra L. Kahane,James C. Lanter,Miriam Alvarez Corral +6 more
TL;DR: A general approach to the synthesis of enantiomerically pure spirocyclic alpha,beta-butenolides is presented where the fundamental framework is rapidly elaborated by acid- or bromonium ion-induced rearrangement of the carbinol derived by addition of 2-lithio-4,5-dihydrofuran to cyclobutanone.
Journal ArticleDOI
Chelation control associated with organometallic addition reactions in water. The high stereoselectivity offered by α- and β-hydroxyl substituents obviates the need for protecting groups
Leo A. Paquette,Thomas M. Mitzel +1 more
TL;DR: In this paper, high stereoselectivities have been observed for indium-promoted allylations of α- and β-hydroxy aldehydes in aqueous media, with strong implication that chelate control can continue to operate in water.
Journal ArticleDOI
Total Synthesis of (+)-Epoxydictymene. Application of Alkoxy-Directed Cyclization to Diterpenoid Construction
TL;DR: In this paper, an enantioselective synthesis of (+)-epoxydictymene (1) is reported, which efficiently constructs the strained oxabicyclo[3.0] octane subunit of 1.3.