Leo Brady

TL;DR: The X-ray structure of the Mucor miehei triglyceride lipase is reported and the atomic model obtained reveals a Ser .. His .. Asp trypsin-like catalytic triad with an active serine buried under a short helical fragment of a long surface loop.

TL;DR: X-ray diffraction analysis of an acid alpha-amylase from Aspergillus niger allowed a detailed description of the stereochemistry of the calcium-binding sites, and a secondary binding site was identified at the bottom of the substrate binding cleft; it involves the residues presumed to play a catalytic role.

TL;DR: It is shown that a single amino acid in transmembrane segment 3 of SERCAs can determine susceptibility to artemisinin, and an L263E replacement of a malarial by a mammalian residue abolishes inhibition by art Artemisinin.

TL;DR: The solution of the structure of this enzyme in a different crystal form, with only one molecule in the asymmetric unit is reported, using a model of acid alpha-amylase from a related fungus A. niger.

TL;DR: Pro_SELECT, a tool for the virtual screening of libraries for fit to a protein active site, has been used to find novel leads against the serine protease factor Xa.