L
Leo E. Gerweck
Researcher at Harvard University
Publications - 101
Citations - 8434
Leo E. Gerweck is an academic researcher from Harvard University. The author has contributed to research in topics: Radiosensitivity & Hyperthermia. The author has an hindex of 41, co-authored 97 publications receiving 8048 citations.
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Journal ArticleDOI
Relative biological effectiveness (RBE) values for proton beam therapy.
Harald Paganetti,Andrzej Niemierko,Marek Ancukiewicz,Leo E. Gerweck,Michael Goitein,Jay S. Loeffler,Herman D. Suit +6 more
TL;DR: There is too much uncertainty in the RBE value for any human tissue to propose RBE values specific for tissue, dose/fraction, proton energy, etc, and experimental in vivo and clinical data indicate that continued employment of a generic RBEvalue is reasonable.
Journal Article
Cellular pH gradient in tumor versus normal tissue : Potential exploitation for the treatment of cancer
Leo E. Gerweck,Kala Seetharaman +1 more
TL;DR: Electro-measured pH values of human tumors and adjacent normal tissues consistently show that the electrode pH is substantially and consistently lower in the tumor than in normal tissue, and the 31P-magnetic resonance spectroscopy estimated that intracellular pH is essentially identical or slightly more basic in tumor compared to normal tissue.
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Cellular responses to combinations of hyperthermia and radiation.
TL;DR: The two principal rationales for applying hyperthermia in cancer therapy are that: the S phase, which is relatively radioresistant, is the most sensitive phase tohyperthermia, and can be selectively radiosensitized by combining hyperThermia with x-irradiation, and the cycling tumor cells in S phase could be killed by subjecting these cells toHyperthermia.
Journal ArticleDOI
The multidrug resistance (mdr1) gene product functions as an ATP channel.
Edward Abraham,A. G. Prat,Leo E. Gerweck,Tara Seneveratne,Robert J. Arceci,Robert A. Kramer,Guido Guidotti,Horacio F. Cantiello +7 more
TL;DR: The data presented here show that cells with increased levels of the P-glycoprotein release ATP to the medium in proportion to the concentration of the protein in their plasma membrane, and measurements of whole-cell and single-channel currents with patch-clamp electrodes indicate that this protein serves as an ATP-conducting channel in the plasma membrane.
Journal ArticleDOI
Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics
TL;DR: The results provide compelling evidence that the pH gradient in a determinant of the efficacy of weak electrolytes in the complex in vivo environment and may be exploited for the treatment of cancer.