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Leo Uzych

Bio: Leo Uzych is an academic researcher. The author has contributed to research in topics: Health care & Self. The author has an hindex of 5, co-authored 6 publications receiving 62 citations.
Topics: Health care, Self

Papers
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Journal ArticleDOI
TL;DR: The most inspiring book today from a very professional writer in the world, a means to an end the biological basis of aging and death 1st issued.
Abstract: Now welcome, the most inspiring book today from a very professional writer in the world, a means to an end the biological basis of aging and death 1st issued. This is the book that many people in the world waiting for to publish. After the announced of this book, the book lovers are really curious to see how this book is actually. Are you one of them? That's very proper. You may not be regret now to seek for this book to read.

18 citations


Cited by
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Journal ArticleDOI
TL;DR: Despite the current lack of empirical evidence for the idea that the rate of mental aging is moderated by amount of mental activity, there may be personal benefits to assuming that the mental-exercise hypothesis is true.
Abstract: It is widely believed that keeping mentally active will prevent age-related mental decline. The primary prediction of this mental-exercise hypothesis is that the rate of age-related decline in measures of cognitive functioning will be less pronounced for people who are more mentally active, or, equivalently, that the cognitive differences among people who vary in level of mental activity will be greater with increased age. Although many training studies, and comparisons involving experts, people in specific occupations, and people whose mental activity levels are determined by their self-reports, have found a positive relation between level of activity and level of cognitive functioning, very few studies have found an interactive effect of age and mental activity on measures of cognitive functioning. Despite the current lack of empirical evidence for the idea that the rate of mental aging is moderated by amount of mental activity, there may be personal benefits to assuming that the mental-exercise hypothesis is true.

561 citations

Journal ArticleDOI
TL;DR: This recent work suggests that progressive chondrocyte senescence marked by expression of thesenescence associated enzyme beta-galactosidase, erosion of chondROcyte telomere length and mitochondrial degeneration due to oxidative damage causes the age related loss of chONDrocytes function.
Abstract: The incidence of osteoarthritis (OA), the disease characterized by joint pain and loss of joint form and function due to articular cartilage degeneration, is directly correlated with age. The strong association between age and increasing incidence of osteoarthritis (OA) marks OA as an age related disease. Yet, like many other age related diseases, OA is not an inevitable consequence of aging; instead, aging increases the risk of OA. Articular cartilage aging changes that may lead to articular cartilage degeneration include fraying and softening of the articular surface, decreased size and aggregation of proteoglycan aggrecans and loss of matrix tensile strength and stiffness. These changes most likely are the result of an age related decrease in the ability of chondrocytes to maintain and repair the tissue manifested by decreased mitotic and synthetic activity, decreased responsiveness to anabolic growth factors and synthesis of smaller less uniform aggrecans and less functional link proteins. Our recent work suggests that progressive chondrocyte senescence marked by expression of the senescence associated enzyme beta-galactosidase, erosion of chondrocyte telomere length and mitochondrial degeneration due to oxidative damage causes the age related loss of chondrocyte function. New efforts to prevent the development and progression of OA might include strategies that slow the progression of chondrocyte senescence or replace senescent cells.

359 citations

Journal ArticleDOI
TL;DR: It is argued that it is necessary to move beyond the simplistic classical expectation and to take a more comprehensive and precise approach to studies of senescence, both theoretically and empirically.
Abstract: A central prediction of classical theories of senescence states that environments posing a high risk of mortality favor the evolution of rapid intrinsic deterioration, or ageing. Although widely cited as being largely corroborated by existing data, empirical support for this prediction has been mixed. Recent theory suggests that this expectation should only be realized under particular circumstances, and this could account for the equivocal empirical findings. Here, we highlight the salient features of some of the recent developments in this field and suggest some ways in which progress might be made. We argue that it is necessary to move beyond the simplistic classical expectation and to take a more comprehensive and precise approach to studies of senescence, both theoretically and empirically.

229 citations

Journal ArticleDOI
TL;DR: In this article, the authors argue that social work is not adequately prepared to practice in the aging society and recommend addressing these challenges through educational innovations, which can make unique professional contributions to older persons and the late-life family.
Abstract: Longevity is one of the great achievements of the 20th century and its implications for the new century will be profound. The unprecedented demographic shift to an increasingly older society will have a dramatic impact on individual choices over the life course, the structure of the family, and multiple social institutions. Social work can make unique professional contributions to older persons and the late-life family. This article asserts, however, that social work is not adequately prepared to practice in the aging society. The authors document the challenges to social work and recommend addressing these challenges through educational innovations.

225 citations

Journal ArticleDOI
TL;DR: The results of this study provide little evidence for the hypothesis that cognitive stimulation preserves or enhances cognitive functioning that would otherwise decline.
Abstract: To make a convincing argument that cognitive stimulation moderates age trends in cognition there must be (a) a negative relation between age and level of cognitive stimulation, (b) a positive relation between level of cognitive stimulation and level of cognitive functioning, and (c) evidence of an interaction between age and cognitive stimulation in the prediction of cognitive functioning. These conditions were investigated in a study in which 204 adults between 20 and 91 years of age completed an activity inventory and performed a variety of cognitive tasks. Only the 1st condition received empirical support, and, thus, the results of this study provide little evidence for the hypothesis that cognitive stimulation preserves or enhances cognitive functioning that would otherwise decline.

156 citations