L
Leonie J. M. J. Delahaye
Researcher at Netherlands Cancer Institute
Publications - 22
Citations - 7160
Leonie J. M. J. Delahaye is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Breast cancer & Follicular lymphoma. The author has an hindex of 9, co-authored 21 publications receiving 6876 citations.
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Journal ArticleDOI
A Gene-Expression Signature as a Predictor of Survival in Breast Cancer
Marc J. van de Vijver,Yudong D. He,Laura J. van't Veer,Hongyue Dai,Augustinus A. M. Hart,D.W. Voskuil,George J. Schreiber,Johannes L. Peterse,Christopher J. Roberts,Matthew J. Marton,Mark Parrish,Douwe Atsma,Anke T. Witteveen,Annuska M. Glas,Leonie J. M. J. Delahaye,Tony van de Velde,Harry Bartelink,Sjoerd Rodenhuis,Emiel J. Th. Rutgers,Stephen H. Friend,René Bernards +20 more
TL;DR: The gene-expression profile studied is a more powerful predictor of the outcome of disease in young patients with breast cancer than standard systems based on clinical and histologic criteria.
Journal ArticleDOI
Converting a breast cancer microarray signature into a high-throughput diagnostic test.
Annuska M. Glas,Arno Floore,Leonie J. M. J. Delahaye,Anke T. Witteveen,Rob Pover,Niels Bakx,Jaana Lahti-Domenici,Tako J. Bruinsma,Marc O. Warmoes,René Bernards,Lodewyk F. A. Wessels,Laura J. van't Veer +11 more
TL;DR: This report demonstrates for the first time that microarray technology can be used as a reliable diagnostic tool and is therefore an excellent tool to predict outcome of disease in breast cancer patients.
Journal ArticleDOI
Gene-expression and immunohistochemical study of specific T-cell subsets and accessory cell types in the transformation and prognosis of follicular lymphoma.
Annuska M. Glas,Laurent Knoops,Leonie J. M. J. Delahaye,Marie José Kersten,Robby E. Kibbelaar,L. F. A. Wessels,Ryan van Laar,J. Han van Krieken,Joke W. Baars,John M. M. Raemaekers,Philip M. Kluin,Laura J. van't Veer,Daphne de Jong +12 more
TL;DR: The identification of FL as an immunologically functional disease in which an interaction of the tumor cells and the functional composition of the microenvironment determines the clinical behavior is supported.
Journal ArticleDOI
Gene expression profiling in follicular lymphoma to assess clinical aggressiveness and to guide the choice of treatment
Annuska M. Glas,Marie José Kersten,Leonie J. M. J. Delahaye,Anke T. Witteveen,Robby E. Kibbelaar,Arno Velds,Lodewyk F. A. Wessels,Peter Joosten,Ron M. Kerkhoven,René Bernards,Johan H. J. M. van Krieken,Philip M. Kluin,Laura J. van't Veer,Daphne de Jong +13 more
TL;DR: The FL stratification profile is a more reliable marker of clinical behavior than the currently used histologic grading and clinical criteria and may provide an important alternative to guide the choice of therapy in patients with FL both at presentation and at relapse.
Journal ArticleDOI
MammaPrint Molecular Diagnostics on Formalin-Fixed, Paraffin-Embedded Tissue
Anna Sapino,Paul Roepman,Sabine C. Linn,Sabine C. Linn,Mireille Snel,Leonie J. M. J. Delahaye,Jeroen van den Akker,Annuska M. Glas,Iris Simon,Neil Barth,Femke De Snoo,Laura J. van't Veer,Luca Molinaro,Els M.J.J. Berns,Jelle Wesseling,Lee B. Riley,David W. Anderson,Bichlien Nguyen,Charles E. Cox +18 more
TL;DR: The method optimization, validation, and performance of MammaPrint using analyte from FFPE tissue, a prognostic 70-gene profile for early-stage breast cancer, are described, and FFPe results are substantially equivalent to results derived from fresh tissue.